Abstract
Several often-cited meta-analyses have reported that the efficacy of antidepressant medications depends on the severity of depression. They found that drug-placebo differences increased as a function of initial severity, which was attributed to decreased responsiveness to placebo among patients with severe depression rather than to increased responsiveness to medication. We retested this using patient-level data and also undertaking a meta-analysis of trial-level data from 34 randomised placebo controlled trials (n = 10 737) from the NEWMEDS registry. Although our trial-level data support prevous findings, patient-level data did not show any significant effect of initial depression severity on drug v. placebo difference.
Original language | English |
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Pages (from-to) | 427-428 |
Number of pages | 2 |
Journal | British Journal of Psychiatry |
Volume | 209 |
Issue number | 5 |
DOIs | |
State | Published - 1 Nov 2016 |
Bibliographical note
Publisher Copyright:© The Royal College of Psychiatrists 2016.
Funding
Funders | Funder number |
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Francine S. Mandel, François Menard, USA; Shitij Kapur, PhD, PhD, School of Social Work, Bar Ilan University, PhD, Pfizer Development Operations, Lundbec Research Department, Department of Psychiatry, University of Texas Health Science Center, Institute of Psychiatry, Psychology and Neuroscience, Kings College London | MRC_G0701748 |
Medical Research Council | G0701748 |