TY - PAT
T1 - Inhibitors of receptor tyrosine kinases and methods of use thereof
AU - Schlessinger, Joseph
AU - Lax, Irit
AU - Yuzawa, Satoru
AU - Opatowsky, Yarden
AU - Yang, Yan
N1 - US Patent 9,273,134
PY - 2016/3/1
Y1 - 2016/3/1
N2 - The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.
AB - The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.
UR - https://patents.google.com/patent/US9273134B2/en
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M1 - US9273134B2
PB - Google Patents,
ER -