Inhibitors of receptor tyrosine kinases and methods of use thereof

Joseph Schlessinger (Inventor), Irit Lax (Inventor), Satoru Yuzawa (Inventor), Yarden Opatowsky (Inventor), Yan Yang (Inventor)

Research output: Patent


The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.
Original languageEnglish
Patent numberUS9273134B2
StatePublished - 1 Mar 2016

Bibliographical note

US Patent 9,273,134


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