Inhibitors of biotin biosynthesis as potential herbicides: Part 2

Tali Ashkenazi, Ayala Widberg, Abraham Nudelman, Vernon Wittenbach, Dennis Flint

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Isosteres and analogues of 7-keto-8-aminopelargonic acid (KAPA) and 7,8-diaminopelargonic acid (DAPA), the vitamer intermediates involved in the biosynthetic pathway of biotin, possessing chain lengths of eight carbon atoms, were prepared and evaluated as potential herbicides. The most active compounds, 7-amino-octanoic acid hydrochloride and 7-allyloxy-6-oxo-octanoic acid, displayed Arabidopsis GR50 (concentration of the active compound that causes a 50% growth inhibition) values of 5 and 10 mg kg-1 respectively. The DAPA analog 6,7-diamino-octanoic acid dihydrochloride, when tested in the greenhouse against six weed species, displayed moderate activity against three species, being most active against foxtail millet.

Original languageEnglish
Pages (from-to)1024-1033
Number of pages10
JournalPest Management Science
Issue number10
StatePublished - Oct 2005


  • Biotin
  • Biotin vitamers
  • Enzyme inhibition
  • Herbicides
  • Isosteres


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