Inhibition of tau-derived hexapeptide aggregation and toxicity by a self-assembled cyclic d,l-α-peptide conformational inhibitor

A. Belostozky; M. Richman; E. Lisniansky; A. Tovchygrechko; J. H. Chill; S. Rahimipour

doi:10.1039/c8cc01233d

Inhibition of tau-derived hexapeptide aggregation and toxicity by a self-assembled cyclic d,l-α-peptide conformational inhibitor

A. Belostozky, M. Richman, E. Lisniansky, A. Tovchygrechko, J. H. Chill, S. Rahimipour

Department of Chemistry

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24 Scopus citations

Abstract

Aggregation and accumulation of amyloid β and tau proteins to plaques and neurofibrillary tangles are the key pathogenic events in Alzheimer's disease. Here, we studied the capability of the cyclic d,l-α-peptide CP-2 as a conformational inhibitor of different amyloids to cross-interact with tau-derived AcPHF6 peptide and inhibit its aggregation, membrane perturbation and toxicity.

Original language	English
Pages (from-to)	5980-5983
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	47
DOIs	https://doi.org/10.1039/c8cc01233d
State	Published - 8 Jun 2018

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© 2018 The Royal Society of Chemistry.

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AU - Chill, J. H.

AU - Rahimipour, S.

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Inhibition of tau-derived hexapeptide aggregation and toxicity by a self-assembled cyclic d,l-α-peptide conformational inhibitor

Abstract

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