Inhibition of acetylcholine receptor synthesis by conditioned medium of electrically stimulated muscle cultures

Asher Shainberg, Ahuva Isac

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In previous studies, it has been reported that electrical stimulation of muscle cultures is followed by inhibition of acetylcholine receptor (AChR) synthesis. In the study reported here, we show that even media taken from electrically stimulated muscle cultures are capable of inhibiting receptor synthesis. This inhibition is specific, since the levels of acetylcholinesterase and creatine kinase are not reduced. The electrically stimulated myotubes probably synthesize and release to the medium a protein(s) responsible for reducing AChR synthesis.

Original languageEnglish
Pages (from-to)373-376
Number of pages4
JournalBrain Research
Volume308
Issue number2
DOIs
StatePublished - 13 Aug 1984

Keywords

  • acetylcholine receptor
  • electric stimulation
  • muscle culture
  • α-bungarotoxin

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