Informatic tools for immunoglobulin gene sequence analysis

Helena Hazanov, Miri Michaeli, Gitit Lavy-Shahaf, Ramit Mehr

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Analyzing immunoglobulin gene sequences, especially in the high throughput sequencing age, raises many challenges. The diverse repertoire and somatic hypermutation they undergo differ the immunoglobulin sequences from other genes, making the commonly used tools unfit for their analysis. Unlike the other genes, immunoglobulins lack a reference gene, raising problems in cleaning the high throughput sequences and defining the germline sequence that will be used as such. Clustering into clones and repertoire representation are nonexistent issues when dealing with uniform genes, but are key analyzes while dealing with immunoglobulin’s. This chapter is a thorough review of the informatics tools that were designed to address the unique nature of the immunoglobulins.

Original languageEnglish
Title of host publicationComparative Immunoglobulin Genetics
PublisherApple Academic Press
Number of pages18
ISBN (Electronic)9781482243550
ISBN (Print)9781771880145
StatePublished - 1 Jan 2014

Bibliographical note

Publisher Copyright:
© 2014 by Apple Academic Press, Inc.


  • Bioinformatics
  • Diversity
  • High throughout sequencing
  • Immunoglobulin genes
  • Immunoinformatics
  • Lineage trees
  • Lymphocytes
  • Repertoire
  • Somatic hypermutation


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