Influenza virus hemagglutinin: Hydrodynamic properties and molecular weight

M. S. Sinyakov, I. G. Kharitonenkov, I. M. Arefiev, A. P. Eskov

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Hydrodynamic properties of hemagglutinin isolated with bromelain from influenza virus were studied. The sedimentation constant determined by the method of analytical ultracentrifugation was 9.17±0.17S. The translation diffusion coefficient estimated by the method of optic mixing spectroscopy comprised (3.6±0.1)x10-7 cm2/s. A combination of both the constants in Svedberg's equation allowed calculation of the hemagglutinin molecular weight (approximately 230,000) which suggests a three-subunit structure of the molecule. The hydrodynamic diameter and friction ratio of an isolated molecule were calculated.

Original languageEnglish
Pages (from-to)42-45
Number of pages4
JournalVoprosy Virusologii
Volume25
Issue number1
StatePublished - 1980
Externally publishedYes

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