Influenza virus antigens conjugated with a synthetic polyelectrolyte: a novel model of vaccines

Rem V. Petrov; Rakhim M. Khaitov; Victor M. Zhdanov; Michael S. Sinyakov; Abdimalik Sh Norimov; Arkadij V. Nekrasov; Raisa Ya Podchernyaeva; Igor G. Kharitonenkov; Marina V. Shchipanova

doi:10.1016/0264-410x(85)90130-6

Influenza virus antigens conjugated with a synthetic polyelectrolyte: a novel model of vaccines

Rem V. Petrov, Rakhim M. Khaitov, Victor M. Zhdanov, Michael S. Sinyakov, Abdimalik Sh Norimov, Arkadij V. Nekrasov, Raisa Ya Podchernyaeva, Igor G. Kharitonenkov, Marina V. Shchipanova

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Haemagglutinin (HA), a mixture of haemagglutinin and neuraminidase (HA + NA), and matrix (M) protein were isolated from the influenza A virus and covalently coupled to a synthetic polyelectrolyte (P). A single injection into mice of the resultant conjugates (virogates) brought about efficient stimulation of the primary immune response specific to the corresponding viral antigens. Mice immunized with virogates HA · P or (HA + NA) · P were largely protected against a lethal challenge infection with homologous virus. Immunization of mice with M · P virogate containing M protein originated from a 1934 influenza strain resulted in pronounced protection against a lethal challenge infection with a 1980 strain. Virogates are discussed as a novel model of artificial vaccines.

Original language	English
Pages (from-to)	392-400
Number of pages	9
Journal	Vaccine
Volume	3
Issue number	5
DOIs	https://doi.org/10.1016/0264-410x(85)90130-6
State	Published - Dec 1985
Externally published	Yes

Keywords

HA
Influenza virus
M
NA
antigenicity
antigens
immunogenicity
polyelectrolyte
virogates

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0264-410x(85)90130-6

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title = "Influenza virus antigens conjugated with a synthetic polyelectrolyte: a novel model of vaccines",

abstract = "Haemagglutinin (HA), a mixture of haemagglutinin and neuraminidase (HA + NA), and matrix (M) protein were isolated from the influenza A virus and covalently coupled to a synthetic polyelectrolyte (P). A single injection into mice of the resultant conjugates (virogates) brought about efficient stimulation of the primary immune response specific to the corresponding viral antigens. Mice immunized with virogates HA · P or (HA + NA) · P were largely protected against a lethal challenge infection with homologous virus. Immunization of mice with M · P virogate containing M protein originated from a 1934 influenza strain resulted in pronounced protection against a lethal challenge infection with a 1980 strain. Virogates are discussed as a novel model of artificial vaccines.",

keywords = "HA, Influenza virus, M, NA, antigenicity, antigens, immunogenicity, polyelectrolyte, virogates",

author = "Petrov, {Rem V.} and Khaitov, {Rakhim M.} and Zhdanov, {Victor M.} and Sinyakov, {Michael S.} and Norimov, {Abdimalik Sh} and Nekrasov, {Arkadij V.} and Podchernyaeva, {Raisa Ya} and Kharitonenkov, {Igor G.} and Shchipanova, {Marina V.}",

year = "1985",

month = dec,

doi = "10.1016/0264-410x(85)90130-6",

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T2 - a novel model of vaccines

AU - Petrov, Rem V.

AU - Khaitov, Rakhim M.

AU - Zhdanov, Victor M.

AU - Sinyakov, Michael S.

AU - Norimov, Abdimalik Sh

AU - Nekrasov, Arkadij V.

AU - Podchernyaeva, Raisa Ya

AU - Kharitonenkov, Igor G.

AU - Shchipanova, Marina V.

PY - 1985/12

Y1 - 1985/12

N2 - Haemagglutinin (HA), a mixture of haemagglutinin and neuraminidase (HA + NA), and matrix (M) protein were isolated from the influenza A virus and covalently coupled to a synthetic polyelectrolyte (P). A single injection into mice of the resultant conjugates (virogates) brought about efficient stimulation of the primary immune response specific to the corresponding viral antigens. Mice immunized with virogates HA · P or (HA + NA) · P were largely protected against a lethal challenge infection with homologous virus. Immunization of mice with M · P virogate containing M protein originated from a 1934 influenza strain resulted in pronounced protection against a lethal challenge infection with a 1980 strain. Virogates are discussed as a novel model of artificial vaccines.

AB - Haemagglutinin (HA), a mixture of haemagglutinin and neuraminidase (HA + NA), and matrix (M) protein were isolated from the influenza A virus and covalently coupled to a synthetic polyelectrolyte (P). A single injection into mice of the resultant conjugates (virogates) brought about efficient stimulation of the primary immune response specific to the corresponding viral antigens. Mice immunized with virogates HA · P or (HA + NA) · P were largely protected against a lethal challenge infection with homologous virus. Immunization of mice with M · P virogate containing M protein originated from a 1934 influenza strain resulted in pronounced protection against a lethal challenge infection with a 1980 strain. Virogates are discussed as a novel model of artificial vaccines.

KW - HA

KW - Influenza virus

KW - M

KW - NA

KW - antigenicity

KW - antigens

KW - immunogenicity

KW - polyelectrolyte

KW - virogates

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EP - 400

JO - Vaccine

JF - Vaccine

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ER -

Influenza virus antigens conjugated with a synthetic polyelectrolyte: a novel model of vaccines

Abstract

Keywords

UN SDGs

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