Influence of physiological parameters on the production of protoporphyrin IX in human skin by topical application of 5-aminolevulinic acid and its hexylester

Mathias von Beckerath; Petras Juzenas; Lennart Löfgren; Li Wei Ma; Vladimir Iani; Zvi Malik; Johan Moan

doi:10.3923/jms.2006.546.553

Influence of physiological parameters on the production of protoporphyrin IX in human skin by topical application of 5-aminolevulinic acid and its hexylester

Mathias von Beckerath, Petras Juzenas, Lennart Löfgren, Li Wei Ma, Vladimir Iani, Zvi Malik, Johan Moan

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Formation of protoporphyrin IX (PpIX) after topical application of 5-aminolevulinic acid (ALA) and its hexylester derivative (ALA-Hex) was studied on healthy human skin. Temperature, density of hair follicles, epidermal and skin thickness were measured on the application sites. The skin temperature was found to be the strongest determinant for PpIX formation. The PpIX fluorescence increase was about 25% per degree Celsius. Formation of PpIX was found to be independent of the density of hair follicles. A weak correlation was found between the PpIX fluorescence and the thickness of epidermis and skin. Sun exposure seems to reduce the production of PpIX slightly.

Original language	English
Pages (from-to)	546-553
Number of pages	8
Journal	Journal of Medical Sciences
Volume	6
Issue number	4
DOIs	https://doi.org/10.3923/jms.2006.546.553
State	Published - Jul 2006

Keywords

5-aminolevulinic acid esters
Epidermal thickness
Fluorescence
Hair follicles
Skin physiology
Skin thickness
Spectroscopy
Temperature

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10.3923/jms.2006.546.553

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title = "Influence of physiological parameters on the production of protoporphyrin IX in human skin by topical application of 5-aminolevulinic acid and its hexylester",

abstract = "Formation of protoporphyrin IX (PpIX) after topical application of 5-aminolevulinic acid (ALA) and its hexylester derivative (ALA-Hex) was studied on healthy human skin. Temperature, density of hair follicles, epidermal and skin thickness were measured on the application sites. The skin temperature was found to be the strongest determinant for PpIX formation. The PpIX fluorescence increase was about 25% per degree Celsius. Formation of PpIX was found to be independent of the density of hair follicles. A weak correlation was found between the PpIX fluorescence and the thickness of epidermis and skin. Sun exposure seems to reduce the production of PpIX slightly.",

keywords = "5-aminolevulinic acid esters, Epidermal thickness, Fluorescence, Hair follicles, Skin physiology, Skin thickness, Spectroscopy, Temperature",

author = "{von Beckerath}, Mathias and Petras Juzenas and Lennart L{\"o}fgren and Ma, {Li Wei} and Vladimir Iani and Zvi Malik and Johan Moan",

year = "2006",

month = jul,

doi = "10.3923/jms.2006.546.553",

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journal = "Journal of Medical Sciences",

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T1 - Influence of physiological parameters on the production of protoporphyrin IX in human skin by topical application of 5-aminolevulinic acid and its hexylester

AU - von Beckerath, Mathias

AU - Juzenas, Petras

AU - Löfgren, Lennart

AU - Ma, Li Wei

AU - Iani, Vladimir

AU - Malik, Zvi

AU - Moan, Johan

PY - 2006/7

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N2 - Formation of protoporphyrin IX (PpIX) after topical application of 5-aminolevulinic acid (ALA) and its hexylester derivative (ALA-Hex) was studied on healthy human skin. Temperature, density of hair follicles, epidermal and skin thickness were measured on the application sites. The skin temperature was found to be the strongest determinant for PpIX formation. The PpIX fluorescence increase was about 25% per degree Celsius. Formation of PpIX was found to be independent of the density of hair follicles. A weak correlation was found between the PpIX fluorescence and the thickness of epidermis and skin. Sun exposure seems to reduce the production of PpIX slightly.

AB - Formation of protoporphyrin IX (PpIX) after topical application of 5-aminolevulinic acid (ALA) and its hexylester derivative (ALA-Hex) was studied on healthy human skin. Temperature, density of hair follicles, epidermal and skin thickness were measured on the application sites. The skin temperature was found to be the strongest determinant for PpIX formation. The PpIX fluorescence increase was about 25% per degree Celsius. Formation of PpIX was found to be independent of the density of hair follicles. A weak correlation was found between the PpIX fluorescence and the thickness of epidermis and skin. Sun exposure seems to reduce the production of PpIX slightly.

KW - 5-aminolevulinic acid esters

KW - Epidermal thickness

KW - Fluorescence

KW - Hair follicles

KW - Skin physiology

KW - Skin thickness

KW - Spectroscopy

KW - Temperature

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Influence of physiological parameters on the production of protoporphyrin IX in human skin by topical application of 5-aminolevulinic acid and its hexylester

Abstract

Keywords

UN SDGs

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