Inflammatory Markers in the Diagnosis of Fibromyalgia

Rola Khamisy-Farah, Eliyahu Fund, Shir Raibman-Spector, Mohammed Adawi

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background: Fibromyalgia syndrome (FMS) is a chronic disorder characterized by widespread musculoskeletal pain accompanied by various additional symptoms. The prevalence of FMS ranges between 2-8% of the population. The exact pathophysiology of the disease remains unknown, and under certain circumstances it is difficult for the physician to diagnose. Previous studies have shown a correlation between inflammatory biomarkers such as C-reactive protein (CRP) and FMS activity, suggesting that an inflammatory component may play a role in this disease pathogenesis. Objectives: To investigate the role of certain new inflammatory biomarkers in the diagnosis of patients with FMS. Methods: In this study data were collected from FMS patients who were admitted to Ziv Medical Center during the period 2013 to 2019 in an attempt to find a connection between inflammatory markers detectable by a traditional complete blood count (CBC) tests such as neutrophil-lymphocytes ratio (NLR), platelet-lymphocyte ratio (PLR), mean platelet value (MPV), red cell distribution width (RDW), and C-reactive protein (CRP) and FMS. Results: We found significantly higher CRP levels, MPV, and PLR and lower lymphocyte count in the FMS group compared to the control group. Conclusions: FMS has certain inflammatory components that may be useful in disease diagnosis.

Original languageEnglish
Pages (from-to)801-804
Number of pages4
JournalIsrael Medical Association Journal
Issue number12
StatePublished - Dec 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 Israel Medical Association. All rights reserved.


  • C-reactive protein (CRP)
  • Fibromyalgia syndrome (FMS)
  • Mean platelet value (MPV)
  • Neutrophil-lymphocyte ratio (NLR)
  • Platelet-lymphocyte ratio (PLR) red cell distribution width (RDW)


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