TY - JOUR
T1 - Infections associated with bendamustine containing regimens in hematological patients
T2 - A retrospective multi-center study
AU - Gafter-Gvili, Anat
AU - Ribakovsky, Elena
AU - Mizrahi, Nadav
AU - Avigdor, Abraham
AU - Aviv, Ariel
AU - Vidal, Liat
AU - Ram, Ron
AU - Perry, Chava
AU - Avivi, Irit
AU - Kedmi, Meirav
AU - Nagler, Arnon
AU - Raanani, Pia
AU - Gurion, Ronit
N1 - Publisher Copyright:
© 2015 Informa UK, Ltd.
PY - 2016/1/2
Y1 - 2016/1/2
N2 - A multi-center retrospective analysis of a cohort of patients in Israel treated with any bendamustine containing regimen between 2010-2014 was performed in order to determine the incidence and predictors for infection. The Kaplan Meier Model, employing log rank analysis, was used to assess time-to-infection. The Cox Proportional Hazards model was used to analyze multivariate effects of risk and 234 patients were included in the analysis. One hundred and nine (46.6%) developed at least one infection and 33.76% had severe infections. Seventy-six (41.5%) developed bacterial infection, nine (3.8%) fungal infection and 26 (11.5%) had viral infections. Factors significantly associated with time to infection on multivariable analysis were: bendamustine-combinations [hazard ratio (HR) = 0.589 (95% CI = 0.374-0.926), p = 0.022], Hb level [HR = 0.791 (95% CI = 0.716-0.875), p < 0.0001] and ischemic heart disease [HR = 1.828 (95% CI = 1.165-2.868), p = 0.009]. Infections were associated with a higher mortality and hospitalization rate.
AB - A multi-center retrospective analysis of a cohort of patients in Israel treated with any bendamustine containing regimen between 2010-2014 was performed in order to determine the incidence and predictors for infection. The Kaplan Meier Model, employing log rank analysis, was used to assess time-to-infection. The Cox Proportional Hazards model was used to analyze multivariate effects of risk and 234 patients were included in the analysis. One hundred and nine (46.6%) developed at least one infection and 33.76% had severe infections. Seventy-six (41.5%) developed bacterial infection, nine (3.8%) fungal infection and 26 (11.5%) had viral infections. Factors significantly associated with time to infection on multivariable analysis were: bendamustine-combinations [hazard ratio (HR) = 0.589 (95% CI = 0.374-0.926), p = 0.022], Hb level [HR = 0.791 (95% CI = 0.716-0.875), p < 0.0001] and ischemic heart disease [HR = 1.828 (95% CI = 1.165-2.868), p = 0.009]. Infections were associated with a higher mortality and hospitalization rate.
KW - Bendamustine
KW - infections
KW - lymphoproliferative disorders
UR - http://www.scopus.com/inward/record.url?scp=84954305386&partnerID=8YFLogxK
U2 - 10.3109/10428194.2015.1046862
DO - 10.3109/10428194.2015.1046862
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C2 - 25944378
AN - SCOPUS:84954305386
SN - 1042-8194
VL - 57
SP - 63
EP - 69
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 1
ER -