TY - JOUR
T1 - Induction of Growth Arrest by a Temperature-Sensitive p53 Mutant Is Correlated with Increased Nuclear Localization and Decreased Stability of the Protein
AU - Ginsberg, Doron
AU - Michael-Michalovitz, Dan
AU - Ginsberg, Dorit
AU - Oren, Moshe
PY - 1991/1
Y1 - 1991/1
N2 - A temperature-sensitive mutant of p53, p53Val-135, was found to be able to arrest cell proliferation when overexpressed at 32.5°C. While much of the protein was cytoplasmic in cells proliferating at 37.5°C, it became predominantly nuclear at 32.5°C. Concomitantly, p53Val-135 became destabilized, although not to the extent seen in primary fibroblasts.
AB - A temperature-sensitive mutant of p53, p53Val-135, was found to be able to arrest cell proliferation when overexpressed at 32.5°C. While much of the protein was cytoplasmic in cells proliferating at 37.5°C, it became predominantly nuclear at 32.5°C. Concomitantly, p53Val-135 became destabilized, although not to the extent seen in primary fibroblasts.
UR - http://www.scopus.com/inward/record.url?scp=0025964061&partnerID=8YFLogxK
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SN - 0270-7306
VL - 11
SP - 582
EP - 585
JO - Molecular and Cellular Biology
JF - Molecular and Cellular Biology
IS - 1
ER -