Inducing inhibition affects propagation of uncertainty and checking behaviors

Difficulty tolerating uncertainty is a central deficit across psychopathologies, and checking behavior is a common response to uncertainty. Inducing inhibition improves resolution of uncertainty. However, it is unclear whether inducing inhibition improves decision-making under conditions of uncertainty or whether it reduces checking. This study evaluated how inducing inhibition affects resolution of uncertainty and checking separately. Healthy adults (N = 34) completed three experiments combining an inhibition-induction task with a novel visual-matching task, which dissociated resolving uncertainty from checking. In Experiment 1, the visual-matching task included only “certainty” trials with unlimited checking. In Experiment 2, the task featured “certainty” and “uncertainty” trials, without checking. In Experiment 3, the task featured “certainty” trials, without checking. All participants completed self-report assessments of relevant clinical constructs including obsessive-compulsive symptoms and depressive symptoms. Our results indicate that inducing inhibition reduces unnecessary checking in “certainty” trials. Inducing inhibition also improves accuracy in “uncertainty” trials when checking is impossible, by limiting the harmful propagation of uncertainty. The propagation of uncertainty correlated with depressive symptoms and checking correlated with obsessive-compulsive symptoms. Our results offer a novel measure of different uncertainty facets and demonstrate the interactions between inhibition, uncertainty, and checking. We also outline implications for understanding specific uncertainty facets in psychopathologies and suggest that inducing inhibition may play a role in alleviating certain mental health symptoms.