TY - JOUR
T1 - Incidence of cancer among diabetic and non-diabetic adult Israeli Arabs
AU - Idilbi, Nasra M.
AU - Barchana, Micha
AU - Milman, Uzi
AU - Carel, Rafael S.
PY - 2013/7
Y1 - 2013/7
N2 - Background: A worldwide epidemic of type 2 diabetes mellitus (T2DM) is in progress. This disease carries a heavy socioeconomic burden. Objectives: To compare the incidence rate of overall and sitespecific cancers among Israeli Arabs with T2DM to that of Israeli Arabs without. Methods: A retrospective cohort study of all adult Arab members of Clalit Health Care Services in northern Israel was conducted over a 10 year period (1999-2008). Results: During the study period 752 and 2045 incident cases of cancer were diagnosed among 13,450 adults with diabetes and 74,484 without, respectively. The follow-up time involved 817,506 person-years. Diabetes was associated with a standard incidence ratio (SIR) of 3.27 (95%CI 1.49-5.05) and 2.87 (95%CI 1.25-4.50) for pancreatic cancer in men and women, respectively. A significantly reduced SIR (0.67, 95%CI 0.36-0.99) was observed for esophageal, stomach and intestinal cancers in men. Conclusions: Our findings support an association between T2DM and increased risk of cancer of the pancreas in Arab men and women. A significantly reduced risk of all other cancers was observed only in Arab men. Our findings underscore the need for effective diabetes and cancer prevention and intervention programs.
AB - Background: A worldwide epidemic of type 2 diabetes mellitus (T2DM) is in progress. This disease carries a heavy socioeconomic burden. Objectives: To compare the incidence rate of overall and sitespecific cancers among Israeli Arabs with T2DM to that of Israeli Arabs without. Methods: A retrospective cohort study of all adult Arab members of Clalit Health Care Services in northern Israel was conducted over a 10 year period (1999-2008). Results: During the study period 752 and 2045 incident cases of cancer were diagnosed among 13,450 adults with diabetes and 74,484 without, respectively. The follow-up time involved 817,506 person-years. Diabetes was associated with a standard incidence ratio (SIR) of 3.27 (95%CI 1.49-5.05) and 2.87 (95%CI 1.25-4.50) for pancreatic cancer in men and women, respectively. A significantly reduced SIR (0.67, 95%CI 0.36-0.99) was observed for esophageal, stomach and intestinal cancers in men. Conclusions: Our findings support an association between T2DM and increased risk of cancer of the pancreas in Arab men and women. A significantly reduced risk of all other cancers was observed only in Arab men. Our findings underscore the need for effective diabetes and cancer prevention and intervention programs.
KW - Cancer incidence
KW - Cohort studies
KW - Computerized databases
KW - Israeli arabs
KW - Type 2 diabetes mellitus (T2DM)
UR - http://www.scopus.com/inward/record.url?scp=84881499380&partnerID=8YFLogxK
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C2 - 23943977
AN - SCOPUS:84881499380
SN - 1565-1088
VL - 15
SP - 342
EP - 347
JO - Israel Medical Association Journal
JF - Israel Medical Association Journal
IS - 7
ER -
