Incessant ovulation, inflammation and epithelial ovarian carcinogenesis: Revisiting old hypotheses

Jean S. Fleming; Clare R. Beaugié; Izhak Haviv; Georgia Chenevix-Trench; Olivia L. Tan

doi:10.1016/j.mce.2005.09.014

Incessant ovulation, inflammation and epithelial ovarian carcinogenesis: Revisiting old hypotheses

Jean S. Fleming, Clare R. Beaugié, Izhak Haviv, Georgia Chenevix-Trench, Olivia L. Tan

Research output: Contribution to journal › Review article › peer-review

154 Scopus citations

Abstract

Epithelial ovarian cancer (EOC) is often a lethal disease because in many cases early symptoms go undetected. Although research proceeds apace, as yet there are few reliable and specific biomarkers for the early stages of the disease. EOC is an umbrella label for a highly heterogeneous collection of cancers, which includes tumours of low malignant potential, serous cystadenomas, mucinous and clear cell carcinomas, all of which are likely to arise from a number of epithelial cell types and a variety of progenitor lesions. Many, but not all types of EOC are thought to arise from the cells lining ovarian inclusion cysts. In this review, we discuss the hypotheses that have driven our ideas on epithelial ovarian carcinogenesis and examine the morphological and genetic evidence for pathways to EOC. The emergence of laser-capture microdissection and expression profiling by microarray technologies offers the promise of defining these pathways more accurately, as well as providing us with the tools for earlier diagnosis.

Original language	English
Pages (from-to)	4-21
Number of pages	18
Journal	Molecular and Cellular Endocrinology
Volume	247
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mce.2005.09.014
State	Published - 9 Mar 2006
Externally published	Yes

Bibliographical note

Funding Information:
The authors are indebted to the technical expertise of H. James McQuillan and Melanie Richardson (Department of Anatomy & Structural Biology, University of Otago, New Zealand). They also acknowledge the work of Naomi Armanasco (Department of Anatomy & Structural Biology, University of Otago, New Zealand) on the effects of talc on the mouse ovary. Research on incessant ovulation of mouse ovaries was supported by the New Zealand Lottery Grants Board (Health), the HS & JC Anderson Trust (Otago, New Zealand) and the University of Otago.

Funding

The authors are indebted to the technical expertise of H. James McQuillan and Melanie Richardson (Department of Anatomy & Structural Biology, University of Otago, New Zealand). They also acknowledge the work of Naomi Armanasco (Department of Anatomy & Structural Biology, University of Otago, New Zealand) on the effects of talc on the mouse ovary. Research on incessant ovulation of mouse ovaries was supported by the New Zealand Lottery Grants Board (Health), the HS & JC Anderson Trust (Otago, New Zealand) and the University of Otago.

Funders	Funder number
HS & JC Anderson Trust
University of Otago
Lotto New Zealand

Keywords

Epithelial ovarian cancer
Inflammation
Ovarian inclusion cyst
Ovulation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.mce.2005.09.014

Cite this

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abstract = "Epithelial ovarian cancer (EOC) is often a lethal disease because in many cases early symptoms go undetected. Although research proceeds apace, as yet there are few reliable and specific biomarkers for the early stages of the disease. EOC is an umbrella label for a highly heterogeneous collection of cancers, which includes tumours of low malignant potential, serous cystadenomas, mucinous and clear cell carcinomas, all of which are likely to arise from a number of epithelial cell types and a variety of progenitor lesions. Many, but not all types of EOC are thought to arise from the cells lining ovarian inclusion cysts. In this review, we discuss the hypotheses that have driven our ideas on epithelial ovarian carcinogenesis and examine the morphological and genetic evidence for pathways to EOC. The emergence of laser-capture microdissection and expression profiling by microarray technologies offers the promise of defining these pathways more accurately, as well as providing us with the tools for earlier diagnosis.",

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Incessant ovulation, inflammation and epithelial ovarian carcinogenesis: Revisiting old hypotheses

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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