Incensole acetate reduces depressive-like behavior and modulates hippocampal BDNF and CRF expression of submissive animals

Arieh Moussaieff, Moshe Gross, Elimelech Nesher, Tatiana Tikhonov, Gal Yadid, Albert Pinhasov

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Incensole acetate (IA), a constituent of Boswellia resin ('frankincense'), was previously demonstrated to exhibit an antidepressive-like effect in the Forced Swim Test (FST) in mice following single dose administration (50 mg/kg). Here, we show that acute administration of considerably lower dose (10 mg/kg) IA to selectively bred mice, showing prominent submissive behavior, exerted significant antidepressant-like effects in the FST. Furthermore, chronic administration of 1 or 5 mg/kg per day of IA for three consecutive weeks dose- and time-dependently reduced the submissiveness of the mice in the Dominant-Submissive Relationship test, developed to screen the chronic effect of antidepressants. This behavioral effect was concomitant to reduced serum corticosterone levels, dose-dependent down-regulation of corticotropin releasing factor and up-regulation of brain derived neurotrophic factor transcripts IV and VI expression in the hippocampus. These data suggest that IA modulates the hypothalamic-pituitary-adrenal (HPA) axis and influences hippocampal gene expression, leading to beneficial behavioral effects supporting its potential as a novel treatment of depressive-like disorders.

Original languageEnglish
Pages (from-to)1584-1593
Number of pages10
JournalJournal of Psychopharmacology
Volume26
Issue number12
DOIs
StatePublished - Dec 2012

Bibliographical note

Funding Information:
This work was supported by the Israel Ministry of Science and Technology.

Funding

This work was supported by the Israel Ministry of Science and Technology.

FundersFunder number
Israel Ministry of Science and Technology

    Keywords

    • Incensole acetate
    • brain derived neurotrophic factor (BDNF)
    • corticosterone
    • corticotrophin releasing factor (CRF)
    • depression
    • dominant-submissive relationship (DSR)

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