TY - JOUR
T1 - In vivo multiparametric monitoring of brain functions under intracranial hypertension following mannitol administration
AU - Barbiro-Michaely, Efrat
AU - Mayevsky, Avraham
AU - Knoller, Nachshon
AU - Hadani, Moshe
PY - 2005/1
Y1 - 2005/1
N2 - Objective: Over the last 20 years, mannitol has replaced other osmotic diuretics. Its beneficial effects on intracranial pressure (ICP), cerebral perfusion pressure (CPP), cerebral blood flow (CBF) and brain metabolism are widely accepted. In the present study, we tested the effect of mannitol injection on brain hemodynamic, metabolic, ionic and electrical state in rats exposed to intracranial hypertension. Methods: The parameters monitored simultaneously included ICP, CBF using the laser Doppler flowmetry, mitochondrial NADH redox state by the fluorometric technique, extracellular K+ and H+ levels, DC potential, ECoG, blood pressure and calculated CPP. ICP was elevated to 30 mmHg for 30 minutes and mannitol was injected 15 minutes post-ICP elevation. Results: Our results showed that mannitol decreased ICP, and improved the levels of MAP, CPP and CBF. Moreover, mannitol completely prevented mortality following intracranial hypertension in rats. Conclusion: It seems that the multiparametric monitoring approach, used in intracranial hypertension models, is an important tool for brain functional state evaluation.
AB - Objective: Over the last 20 years, mannitol has replaced other osmotic diuretics. Its beneficial effects on intracranial pressure (ICP), cerebral perfusion pressure (CPP), cerebral blood flow (CBF) and brain metabolism are widely accepted. In the present study, we tested the effect of mannitol injection on brain hemodynamic, metabolic, ionic and electrical state in rats exposed to intracranial hypertension. Methods: The parameters monitored simultaneously included ICP, CBF using the laser Doppler flowmetry, mitochondrial NADH redox state by the fluorometric technique, extracellular K+ and H+ levels, DC potential, ECoG, blood pressure and calculated CPP. ICP was elevated to 30 mmHg for 30 minutes and mannitol was injected 15 minutes post-ICP elevation. Results: Our results showed that mannitol decreased ICP, and improved the levels of MAP, CPP and CBF. Moreover, mannitol completely prevented mortality following intracranial hypertension in rats. Conclusion: It seems that the multiparametric monitoring approach, used in intracranial hypertension models, is an important tool for brain functional state evaluation.
KW - Cerebral blood flow
KW - Elevated ICP
KW - Extracellular K
KW - Mannitol
KW - Mitochondrial redox state
KW - NADH fluorometry
UR - http://www.scopus.com/inward/record.url?scp=13244256946&partnerID=8YFLogxK
U2 - 10.1179/016164105x18377
DO - 10.1179/016164105x18377
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C2 - 15829166
AN - SCOPUS:13244256946
SN - 0161-6412
VL - 27
SP - 88
EP - 93
JO - Neurological Research
JF - Neurological Research
IS - 1
ER -