TY - JOUR
T1 - In vivo anomalous diffusion and weak ergodicity breaking of lipid granules
AU - Jeon, Jae Hyung
AU - Tejedor, Vincent
AU - Burov, Stas
AU - Barkai, Eli
AU - Selhuber-Unkel, Christine
AU - Berg-Sørensen, Kirstine
AU - Oddershede, Lene
AU - Metzler, Ralf
PY - 2011/1/28
Y1 - 2011/1/28
N2 - Combining extensive single particle tracking microscopy data of endogenous lipid granules in living fission yeast cells with analytical results we show evidence for anomalous diffusion and weak ergodicity breaking. Namely we demonstrate that at short times the granules perform subdiffusion according to the laws of continuous time random walk theory. The associated violation of ergodicity leads to a characteristic turnover between two scaling regimes of the time averaged mean squared displacement. At longer times the granule motion is consistent with fractional Brownian motion.
AB - Combining extensive single particle tracking microscopy data of endogenous lipid granules in living fission yeast cells with analytical results we show evidence for anomalous diffusion and weak ergodicity breaking. Namely we demonstrate that at short times the granules perform subdiffusion according to the laws of continuous time random walk theory. The associated violation of ergodicity leads to a characteristic turnover between two scaling regimes of the time averaged mean squared displacement. At longer times the granule motion is consistent with fractional Brownian motion.
UR - http://www.scopus.com/inward/record.url?scp=79251477200&partnerID=8YFLogxK
U2 - 10.1103/PhysRevLett.106.048103
DO - 10.1103/PhysRevLett.106.048103
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C2 - 21405366
AN - SCOPUS:79251477200
SN - 0031-9007
VL - 106
JO - Physical Review Letters
JF - Physical Review Letters
IS - 4
M1 - 048103
ER -