In vivo anomalous diffusion and weak ergodicity breaking of lipid granules

Jae Hyung Jeon, Vincent Tejedor, Stas Burov, Eli Barkai, Christine Selhuber-Unkel, Kirstine Berg-Sørensen, Lene Oddershede, Ralf Metzler

Research output: Contribution to journalArticlepeer-review

567 Scopus citations


Combining extensive single particle tracking microscopy data of endogenous lipid granules in living fission yeast cells with analytical results we show evidence for anomalous diffusion and weak ergodicity breaking. Namely we demonstrate that at short times the granules perform subdiffusion according to the laws of continuous time random walk theory. The associated violation of ergodicity leads to a characteristic turnover between two scaling regimes of the time averaged mean squared displacement. At longer times the granule motion is consistent with fractional Brownian motion.

Original languageEnglish
Article number048103
JournalPhysical Review Letters
Issue number4
StatePublished - 28 Jan 2011


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