In vitro fertilization and primary embryonic cleavage are possible in 17α-hydroxylase deficiency despite extremely low intrafollicular 17β-estradiol

Jaron Rabinovici; Josef Blankstein; Boleslav Goldman; Edvina Rudak; Yehoshua Dor; Clara Pariente; Abraham Geier; Bruno Lunenfeld; Shlomo Mashiach

doi:10.1210/jcem-68-3-693

In vitro fertilization and primary embryonic cleavage are possible in 17α-hydroxylase deficiency despite extremely low intrafollicular 17β-estradiol

Jaron Rabinovici
, Josef Blankstein
, Boleslav Goldman
, Edvina Rudak
, Yehoshua Dor
, Clara Pariente
, Abraham Geier
, Bruno Lunenfeld
, Shlomo Mashiach

Sheba Medical Center at Tel Hashomer
Tel Aviv University

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Abstract

Congenital adrenal hyperplasia due to 17α-hy-droxylase deficiency in genotypic females is characterized by primary amenorrhea and the absence of sexual maturation due to inadequate biosynthesis of ovarian androgens and estrogens. We induced ovarian follicular development in a woman with this syndrome. Ovum pick-up, in vitro fertilization, and primary embryonic development were achieved despite undetectable plasma estradiol and extremely low ovarian androgen concentrations and minute concentrations of these hormones in the ovarian follicular fluid.

Original language	English
Pages (from-to)	693-697
Number of pages	5
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	68
Issue number	3
DOIs	https://doi.org/10.1210/jcem-68-3-693
State	Published - Mar 1989
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1210/jcem-68-3-693

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Rabinovici, J., Blankstein, J., Goldman, B., Rudak, E., Dor, Y., Pariente, C., Geier, A., Lunenfeld, B., & Mashiach, S. (1989). In vitro fertilization and primary embryonic cleavage are possible in 17α-hydroxylase deficiency despite extremely low intrafollicular 17β-estradiol. Journal of Clinical Endocrinology and Metabolism, 68(3), 693-697. https://doi.org/10.1210/jcem-68-3-693

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title = "In vitro fertilization and primary embryonic cleavage are possible in 17α-hydroxylase deficiency despite extremely low intrafollicular 17β-estradiol",

abstract = "Congenital adrenal hyperplasia due to 17α-hy-droxylase deficiency in genotypic females is characterized by primary amenorrhea and the absence of sexual maturation due to inadequate biosynthesis of ovarian androgens and estrogens. We induced ovarian follicular development in a woman with this syndrome. Ovum pick-up, in vitro fertilization, and primary embryonic development were achieved despite undetectable plasma estradiol and extremely low ovarian androgen concentrations and minute concentrations of these hormones in the ovarian follicular fluid.",

author = "Jaron Rabinovici and Josef Blankstein and Boleslav Goldman and Edvina Rudak and Yehoshua Dor and Clara Pariente and Abraham Geier and Bruno Lunenfeld and Shlomo Mashiach",

year = "1989",

month = mar,

doi = "10.1210/jcem-68-3-693",

language = "אנגלית",

volume = "68",

pages = "693--697",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "0021-972X",

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Rabinovici, J, Blankstein, J, Goldman, B, Rudak, E, Dor, Y, Pariente, C, Geier, A, Lunenfeld, B & Mashiach, S 1989, 'In vitro fertilization and primary embryonic cleavage are possible in 17α-hydroxylase deficiency despite extremely low intrafollicular 17β-estradiol', Journal of Clinical Endocrinology and Metabolism, vol. 68, no. 3, pp. 693-697. https://doi.org/10.1210/jcem-68-3-693

In vitro fertilization and primary embryonic cleavage are possible in 17α-hydroxylase deficiency despite extremely low intrafollicular 17β-estradiol. / Rabinovici, Jaron; Blankstein, Josef; Goldman, Boleslav et al.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 68, No. 3, 03.1989, p. 693-697.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - In vitro fertilization and primary embryonic cleavage are possible in 17α-hydroxylase deficiency despite extremely low intrafollicular 17β-estradiol

AU - Rabinovici, Jaron

AU - Blankstein, Josef

AU - Goldman, Boleslav

AU - Rudak, Edvina

AU - Dor, Yehoshua

AU - Pariente, Clara

AU - Geier, Abraham

AU - Lunenfeld, Bruno

AU - Mashiach, Shlomo

PY - 1989/3

Y1 - 1989/3

N2 - Congenital adrenal hyperplasia due to 17α-hy-droxylase deficiency in genotypic females is characterized by primary amenorrhea and the absence of sexual maturation due to inadequate biosynthesis of ovarian androgens and estrogens. We induced ovarian follicular development in a woman with this syndrome. Ovum pick-up, in vitro fertilization, and primary embryonic development were achieved despite undetectable plasma estradiol and extremely low ovarian androgen concentrations and minute concentrations of these hormones in the ovarian follicular fluid.

AB - Congenital adrenal hyperplasia due to 17α-hy-droxylase deficiency in genotypic females is characterized by primary amenorrhea and the absence of sexual maturation due to inadequate biosynthesis of ovarian androgens and estrogens. We induced ovarian follicular development in a woman with this syndrome. Ovum pick-up, in vitro fertilization, and primary embryonic development were achieved despite undetectable plasma estradiol and extremely low ovarian androgen concentrations and minute concentrations of these hormones in the ovarian follicular fluid.

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AN - SCOPUS:0024598782

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JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 3

ER -

In vitro fertilization and primary embryonic cleavage are possible in 17α-hydroxylase deficiency despite extremely low intrafollicular 17β-estradiol

Abstract

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