In vitro fertilization and primary embryonic cleavage are possible in 17α-hydroxylase deficiency despite extremely low intrafollicular 17β-estradiol

Jaron Rabinovici, Josef Blankstein, Boleslav Goldman, Edvina Rudak, Yehoshua Dor, Clara Pariente, Abraham Geier, Bruno Lunenfeld, Shlomo Mashiach

Research output: Contribution to journalArticlepeer-review

130 Scopus citations

Abstract

Congenital adrenal hyperplasia due to 17α-hy-droxylase deficiency in genotypic females is characterized by primary amenorrhea and the absence of sexual maturation due to inadequate biosynthesis of ovarian androgens and estrogens. We induced ovarian follicular development in a woman with this syndrome. Ovum pick-up, in vitro fertilization, and primary embryonic development were achieved despite undetectable plasma estradiol and extremely low ovarian androgen concentrations and minute concentrations of these hormones in the ovarian follicular fluid.

Original languageEnglish
Pages (from-to)693-697
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume68
Issue number3
DOIs
StatePublished - Mar 1989
Externally publishedYes

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