TY - JOUR
T1 - In vitro fertilization and primary embryonic cleavage are possible in 17α-hydroxylase deficiency despite extremely low intrafollicular 17β-estradiol
AU - Rabinovici, Jaron
AU - Blankstein, Josef
AU - Goldman, Boleslav
AU - Rudak, Edvina
AU - Dor, Yehoshua
AU - Pariente, Clara
AU - Geier, Abraham
AU - Lunenfeld, Bruno
AU - Mashiach, Shlomo
PY - 1989/3
Y1 - 1989/3
N2 - Congenital adrenal hyperplasia due to 17α-hy-droxylase deficiency in genotypic females is characterized by primary amenorrhea and the absence of sexual maturation due to inadequate biosynthesis of ovarian androgens and estrogens. We induced ovarian follicular development in a woman with this syndrome. Ovum pick-up, in vitro fertilization, and primary embryonic development were achieved despite undetectable plasma estradiol and extremely low ovarian androgen concentrations and minute concentrations of these hormones in the ovarian follicular fluid.
AB - Congenital adrenal hyperplasia due to 17α-hy-droxylase deficiency in genotypic females is characterized by primary amenorrhea and the absence of sexual maturation due to inadequate biosynthesis of ovarian androgens and estrogens. We induced ovarian follicular development in a woman with this syndrome. Ovum pick-up, in vitro fertilization, and primary embryonic development were achieved despite undetectable plasma estradiol and extremely low ovarian androgen concentrations and minute concentrations of these hormones in the ovarian follicular fluid.
UR - http://www.scopus.com/inward/record.url?scp=0024598782&partnerID=8YFLogxK
U2 - 10.1210/jcem-68-3-693
DO - 10.1210/jcem-68-3-693
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C2 - 2493041
AN - SCOPUS:0024598782
SN - 0021-972X
VL - 68
SP - 693
EP - 697
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 3
ER -
