Although most immunologists do not routinely combine experiments with theoretical and mathematical modeling, new insights can be gained from this interdisciplinary approach. But what makes a good theoretical model?
Bibliographical noteFunding Information:
We thank T.A. Springer and D. Leja for images in Figure 1, and M.M. Davis, S.Y. Qi, A.R. Dinner, R.N. Germain, S. Raychaudhuri, Y. Hori, J.T. Groves and S.J. Lee for discussions on the involvement of modeling in cellular immunology. Supported by the National Institutes of Health.