In search of critical dsRNA targets of ADAR1

Erez Y. Levanon; Roni Cohen-Fultheim; Eli Eisenberg

doi:10.1016/j.tig.2023.12.002

In search of critical dsRNA targets of ADAR1

Erez Y. Levanon, Roni Cohen-Fultheim, Eli Eisenberg

The Mina and Everard Goodman Faculty of Life Sciences

Tel Aviv University

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Recent studies have underscored the pivotal role of adenosine-to-inosine RNA editing, catalyzed by ADAR1, in suppressing innate immune interferon responses triggered by cellular double-stranded RNA (dsRNA). However, the specific ADAR1 editing targets crucial for this regulatory function remain elusive. We review analyses of transcriptome-wide ADAR1 editing patterns and their evolutionary dynamics, which offer valuable insights into this unresolved query. The growing appreciation of the significance of immunogenic dsRNAs and their editing in inflammatory and autoimmune diseases and cancer calls for a more comprehensive understanding of dsRNA immunogenicity, which may promote our understanding of these diseases and open doors to therapeutic avenues.

Original language	English
Pages (from-to)	250-259
Number of pages	10
Journal	Trends in Genetics
Volume	40
Issue number	3
DOIs	https://doi.org/10.1016/j.tig.2023.12.002
State	Published - Mar 2024

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Ltd

Funding

E.Y.L. was funded by the EU (cenceRNA consortium) and by Israel Science Foundation (ISF) grant 2637/23 . E.E. was funded by ISF grant 1945/18 . Figures were created with BioRender.com .

Funders	Funder number
European Commission
Israel Science Foundation	1945/18, 2637/23

Keywords

ADAR
MDA5
RNA editing
double-stranded RNA
innate immunity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tig.2023.12.002

Cite this

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abstract = "Recent studies have underscored the pivotal role of adenosine-to-inosine RNA editing, catalyzed by ADAR1, in suppressing innate immune interferon responses triggered by cellular double-stranded RNA (dsRNA). However, the specific ADAR1 editing targets crucial for this regulatory function remain elusive. We review analyses of transcriptome-wide ADAR1 editing patterns and their evolutionary dynamics, which offer valuable insights into this unresolved query. The growing appreciation of the significance of immunogenic dsRNAs and their editing in inflammatory and autoimmune diseases and cancer calls for a more comprehensive understanding of dsRNA immunogenicity, which may promote our understanding of these diseases and open doors to therapeutic avenues.",

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AB - Recent studies have underscored the pivotal role of adenosine-to-inosine RNA editing, catalyzed by ADAR1, in suppressing innate immune interferon responses triggered by cellular double-stranded RNA (dsRNA). However, the specific ADAR1 editing targets crucial for this regulatory function remain elusive. We review analyses of transcriptome-wide ADAR1 editing patterns and their evolutionary dynamics, which offer valuable insights into this unresolved query. The growing appreciation of the significance of immunogenic dsRNAs and their editing in inflammatory and autoimmune diseases and cancer calls for a more comprehensive understanding of dsRNA immunogenicity, which may promote our understanding of these diseases and open doors to therapeutic avenues.

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In search of critical dsRNA targets of ADAR1

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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