TY - JOUR
T1 - Improving the excess kurtosis (g2) method for localizing epileptic sources in magnetoencephalographic recordings
AU - Harpaz, Yuval
AU - Robinson, Stephen E.
AU - Medvedovsky, Mordekhay
AU - Goldstein, Abraham
N1 - Publisher Copyright:
© 2014 International Federation of Clinical Neurophysiology.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Objective: To suggest ways to apply the excess kurtosis estimator g2, in the detection of epileptic activity with magnetoencephalography, while avoiding its bias towards detecting high-amplitude, infrequent events. Methods: Synthetic aperture magnetometry (SAM), combined with g2, was applied using window lengths ranging from 0.125s to 32s and with sum and maximum metrics on simulated data and recordings of two focal epilepsy patients. Results: Comparing sources with different spike rates (two per second and one per 2s), the sum metric was most efficient when using a window of 0.25s. Simulations showed that the sum metric is insensitive to spike frequency when the window includes more than one spike. SAM(g2) images from long segments with maximum metric resulted in misleading images, showing the strongest activity away from the lesions. Conclusions: Using a sliding window and the sum metric is beneficial when imaging interictal spikes and status epilepticus. Windows should be short enough not to include more than one interictal event. For continuous events such as electrographic seizures windows should contain baseline data and the epileptic event. Significance: The sliding window and metric should be set according to the suggested guidelines when using SAM(g2) for presurgical evaluation.
AB - Objective: To suggest ways to apply the excess kurtosis estimator g2, in the detection of epileptic activity with magnetoencephalography, while avoiding its bias towards detecting high-amplitude, infrequent events. Methods: Synthetic aperture magnetometry (SAM), combined with g2, was applied using window lengths ranging from 0.125s to 32s and with sum and maximum metrics on simulated data and recordings of two focal epilepsy patients. Results: Comparing sources with different spike rates (two per second and one per 2s), the sum metric was most efficient when using a window of 0.25s. Simulations showed that the sum metric is insensitive to spike frequency when the window includes more than one spike. SAM(g2) images from long segments with maximum metric resulted in misleading images, showing the strongest activity away from the lesions. Conclusions: Using a sliding window and the sum metric is beneficial when imaging interictal spikes and status epilepticus. Windows should be short enough not to include more than one interictal event. For continuous events such as electrographic seizures windows should contain baseline data and the epileptic event. Significance: The sliding window and metric should be set according to the suggested guidelines when using SAM(g2) for presurgical evaluation.
KW - Beamforming
KW - Epilepsy
KW - Kurtosis
KW - Source localization
KW - Spike
UR - http://www.scopus.com/inward/record.url?scp=84926229499&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2014.09.002
DO - 10.1016/j.clinph.2014.09.002
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 25281474
AN - SCOPUS:84926229499
SN - 1388-2457
VL - 126
SP - 889
EP - 897
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
IS - 5
ER -