Improved Geometric Configuration for the Bladder Cancer BCG-Based Immunotherapy Treatment Model

Teddy Lazebnik, Svetlana Bunimovich-Mendrazitsky

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Bacillus Calmette–Guérin (BCG) immunotherapy has shown significant success for bladder cancer treatment, but due to the lack of personalization, it does not fulfill its full promise as the interaction between immunity and cancer varies significantly between patients and results in extremely different clinical outcomes. As personalized treatment developed, it is important to take into consideration the geometrical configuration of the bladder in order to get realistic results using spatio-temporal treatment models. We present an extension to the model proposed by Lazebnik et al. [9] by improving the approximation of the bladder’s geometry from sphere-ring to ellipsoid-ring [8]. We show the differences between the models on the clinical results and their influence on the optimal treatment protocol.

Original languageEnglish
Title of host publicationMathematical and Computational Oncology - Third International Symposium, ISMCO 2021, Proceedings
EditorsGeorge Bebis, Terry Gaasterland, Mamoru Kato, Mohammad Kohandel, Kathleen Wilkie
PublisherSpringer Science and Business Media Deutschland GmbH
Pages63-67
Number of pages5
ISBN (Print)9783030912406
DOIs
StatePublished - 2021
Externally publishedYes
Event3rd International Symposium on Mathematical and Computational Oncology, ISMCO 2021 - Virtual, Online
Duration: 11 Oct 202113 Oct 2021

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume13060 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference3rd International Symposium on Mathematical and Computational Oncology, ISMCO 2021
CityVirtual, Online
Period11/10/2113/10/21

Bibliographical note

Publisher Copyright:
© 2021, Springer Nature Switzerland AG.

Keywords

  • Geometrical pde systems dynamics
  • Nonlinear systems
  • PDE cancer treatment model

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