Improved Geometric Configuration for the Bladder Cancer BCG-Based Immunotherapy Treatment Model

Teddy Lazebnik; Svetlana Bunimovich-Mendrazitsky

doi:10.1007/978-3-030-91241-3_6

Improved Geometric Configuration for the Bladder Cancer BCG-Based Immunotherapy Treatment Model

Teddy Lazebnik, Svetlana Bunimovich-Mendrazitsky

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

Bacillus Calmette–Guérin (BCG) immunotherapy has shown significant success for bladder cancer treatment, but due to the lack of personalization, it does not fulfill its full promise as the interaction between immunity and cancer varies significantly between patients and results in extremely different clinical outcomes. As personalized treatment developed, it is important to take into consideration the geometrical configuration of the bladder in order to get realistic results using spatio-temporal treatment models. We present an extension to the model proposed by Lazebnik et al. [9] by improving the approximation of the bladder’s geometry from sphere-ring to ellipsoid-ring [8]. We show the differences between the models on the clinical results and their influence on the optimal treatment protocol.

Original language	English
Title of host publication	Mathematical and Computational Oncology - Third International Symposium, ISMCO 2021, Proceedings
Editors	George Bebis, Terry Gaasterland, Mamoru Kato, Mohammad Kohandel, Kathleen Wilkie
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	63-67
Number of pages	5
ISBN (Print)	9783030912406
DOIs	https://doi.org/10.1007/978-3-030-91241-3_6
State	Published - 2021
Externally published	Yes
Event	3rd International Symposium on Mathematical and Computational Oncology, ISMCO 2021 - Virtual, Online Duration: 11 Oct 2021 → 13 Oct 2021

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	13060 LNBI
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	3rd International Symposium on Mathematical and Computational Oncology, ISMCO 2021
City	Virtual, Online
Period	11/10/21 → 13/10/21

Bibliographical note

Publisher Copyright:
© 2021, Springer Nature Switzerland AG.

Keywords

Geometrical pde systems dynamics
Nonlinear systems
PDE cancer treatment model

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-030-91241-3_6

Cite this

Lazebnik, T., & Bunimovich-Mendrazitsky, S. (2021). Improved Geometric Configuration for the Bladder Cancer BCG-Based Immunotherapy Treatment Model. In G. Bebis, T. Gaasterland, M. Kato, M. Kohandel, & K. Wilkie (Eds.), Mathematical and Computational Oncology - Third International Symposium, ISMCO 2021, Proceedings (pp. 63-67). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 13060 LNBI). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-030-91241-3_6

Lazebnik, Teddy ; Bunimovich-Mendrazitsky, Svetlana. / Improved Geometric Configuration for the Bladder Cancer BCG-Based Immunotherapy Treatment Model. Mathematical and Computational Oncology - Third International Symposium, ISMCO 2021, Proceedings. editor / George Bebis ; Terry Gaasterland ; Mamoru Kato ; Mohammad Kohandel ; Kathleen Wilkie. Springer Science and Business Media Deutschland GmbH, 2021. pp. 63-67 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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Lazebnik, T & Bunimovich-Mendrazitsky, S 2021, Improved Geometric Configuration for the Bladder Cancer BCG-Based Immunotherapy Treatment Model. in G Bebis, T Gaasterland, M Kato, M Kohandel & K Wilkie (eds), Mathematical and Computational Oncology - Third International Symposium, ISMCO 2021, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 13060 LNBI, Springer Science and Business Media Deutschland GmbH, pp. 63-67, 3rd International Symposium on Mathematical and Computational Oncology, ISMCO 2021, Virtual, Online, 11/10/21. https://doi.org/10.1007/978-3-030-91241-3_6

Improved Geometric Configuration for the Bladder Cancer BCG-Based Immunotherapy Treatment Model. / Lazebnik, Teddy; Bunimovich-Mendrazitsky, Svetlana.
Mathematical and Computational Oncology - Third International Symposium, ISMCO 2021, Proceedings. ed. / George Bebis; Terry Gaasterland; Mamoru Kato; Mohammad Kohandel; Kathleen Wilkie. Springer Science and Business Media Deutschland GmbH, 2021. p. 63-67 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 13060 LNBI).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Lazebnik T, Bunimovich-Mendrazitsky S. Improved Geometric Configuration for the Bladder Cancer BCG-Based Immunotherapy Treatment Model. In Bebis G, Gaasterland T, Kato M, Kohandel M, Wilkie K, editors, Mathematical and Computational Oncology - Third International Symposium, ISMCO 2021, Proceedings. Springer Science and Business Media Deutschland GmbH. 2021. p. 63-67. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/978-3-030-91241-3_6

Improved Geometric Configuration for the Bladder Cancer BCG-Based Immunotherapy Treatment Model

Abstract

Publication series

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Bibliographical note

Keywords

UN SDGs

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