Improved borders detection of areas enriched with gold nanoparticles inside biological phantom

Yossef Danan; Zeev Zalevsky; Moshe Sinvani

doi:10.1117/12.2253695

Improved borders detection of areas enriched with gold nanoparticles inside biological phantom

Yossef Danan, Zeev Zalevsky, Moshe Sinvani

Bar-Ilan University - The Alexander Kofkin Faculty of Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Utilizing the surface plasmon resonance (SPR) effect of gold nanoparticles (GNPs) enables their using as contrast agents in a variety of biomedical applications for diagnostics and treatment. These applications use both the very strong scattering and absorption properties of the GNPs due to their SPR effects. Most imaging methods use the light-scattering properties of the GNPs. However, the illumination source is in the same wavelength of the GNPs scattering wavelength, leading to background noise caused by light scattering from the tissue. In this paper we present a method to improve border detection of regions enriched with GNPs aiming for real time application of complete tumor resection by utilizing the absorption of specially targeted GNPs using photothermal imaging. Phantoms containing different concentrations of GNPs were irradiated with continuous-wave laser and measured with a thermal imaging camera which detected the temperature field of the irradiated phantoms. By modulating the laser illumination, and use of a simple post processing, the border location was identified in accuracy of better than 0.5 mm even when the surrounding area get heated. This work is in continuation to our previous research¹.

Original language	English
Title of host publication	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV
Editors	Dan V. Nicolau, Dror Fixler, Alexander N. Cartwright
Publisher	SPIE
ISBN (Electronic)	9781510605954
DOIs	https://doi.org/10.1117/12.2253695
State	Published - 2017
Event	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV 2017 - San Francisco, United States Duration: 30 Jan 2017 → 1 Feb 2017

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	10077
ISSN (Print)	1605-7422

Conference

Conference	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV 2017
Country/Territory	United States
City	San Francisco
Period	30/01/17 → 1/02/17

Bibliographical note

Publisher Copyright:
© 2017 SPIE.

Keywords

Gold nanorods
Laser beam modulation
Photothermal imaging
Surface plasmon resonance

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10.1117/12.2253695

Cite this

Danan, Y., Zalevsky, Z., & Sinvani, M. (2017). Improved borders detection of areas enriched with gold nanoparticles inside biological phantom. In D. V. Nicolau, D. Fixler, & A. N. Cartwright (Eds.), Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV Article 100770F (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10077). SPIE. https://doi.org/10.1117/12.2253695

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title = "Improved borders detection of areas enriched with gold nanoparticles inside biological phantom",

abstract = "Utilizing the surface plasmon resonance (SPR) effect of gold nanoparticles (GNPs) enables their using as contrast agents in a variety of biomedical applications for diagnostics and treatment. These applications use both the very strong scattering and absorption properties of the GNPs due to their SPR effects. Most imaging methods use the light-scattering properties of the GNPs. However, the illumination source is in the same wavelength of the GNPs scattering wavelength, leading to background noise caused by light scattering from the tissue. In this paper we present a method to improve border detection of regions enriched with GNPs aiming for real time application of complete tumor resection by utilizing the absorption of specially targeted GNPs using photothermal imaging. Phantoms containing different concentrations of GNPs were irradiated with continuous-wave laser and measured with a thermal imaging camera which detected the temperature field of the irradiated phantoms. By modulating the laser illumination, and use of a simple post processing, the border location was identified in accuracy of better than 0.5 mm even when the surrounding area get heated. This work is in continuation to our previous research1.",

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author = "Yossef Danan and Zeev Zalevsky and Moshe Sinvani",

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Danan, Y, Zalevsky, Z & Sinvani, M 2017, Improved borders detection of areas enriched with gold nanoparticles inside biological phantom. in DV Nicolau, D Fixler & AN Cartwright (eds), Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV., 100770F, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10077, SPIE, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV 2017, San Francisco, United States, 30/01/17. https://doi.org/10.1117/12.2253695

Improved borders detection of areas enriched with gold nanoparticles inside biological phantom. / Danan, Yossef; Zalevsky, Zeev; Sinvani, Moshe.
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV. ed. / Dan V. Nicolau; Dror Fixler; Alexander N. Cartwright. SPIE, 2017. 100770F (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10077).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Improved borders detection of areas enriched with gold nanoparticles inside biological phantom

Abstract

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Keywords

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