Importin beta: Conducting a much larger cellular symphony

Amnon Harel; Douglass J. Forbes

doi:10.1016/j.molcel.2004.10.026

Importin beta: Conducting a much larger cellular symphony

Amnon Harel
, Douglass J. Forbes

Research output: Contribution to journal › Review article › peer-review

321 Scopus citations

Abstract

Importin β, once thought to be exclusively a nuclear transport receptor, is emerging as a global regulator of diverse cellular functions. Importin β acts positively in multiple interphase roles: in nuclear import, as a chaperone for highly charged nuclear proteins, and as a potential motor adaptor for movement along microtubules. In contrast, importin β plays a negative regulatory role in mitotic spindle assembly, centrosome dynamics, nuclear membrane formation, and nuclear pore assembly. In most of these, importin β is counteracted by its regulator, Ran-GTP. In light of this, the recent discovery of Ran's involvement in spindle checkpoint control suggested a potential new arena for importin β action, although it is also possible that one of importin β's relatives, the karyopherin family of proteins, manages this checkpoint. Lastly, importin β plays a role in transducing damage signals from the axons of injured neurons back to the cell body.

Original language	English
Pages (from-to)	319-330
Number of pages	12
Journal	Molecular Cell
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2004.10.026
State	Published - 5 Nov 2004
Externally published	Yes

Bibliographical note

Funding Information:
The current papers concerning importin β and the karyopherins number close to a thousand; the authors regret that only a fraction could be cited. The authors were supported by National Institutes of Health grant R01-GM033279 to D.J.F. and a United States-Israel Bi-national Sciences Foundation Grant 200295 to D.F. and Michael Elbaum (Weizmann Institute, Rehovot, Israel). The authors thank Rene Chan, Valerie Delmar, and Corine Lau for help in preparing the manuscript.

Funding

The current papers concerning importin β and the karyopherins number close to a thousand; the authors regret that only a fraction could be cited. The authors were supported by National Institutes of Health grant R01-GM033279 to D.J.F. and a United States-Israel Bi-national Sciences Foundation Grant 200295 to D.F. and Michael Elbaum (Weizmann Institute, Rehovot, Israel). The authors thank Rene Chan, Valerie Delmar, and Corine Lau for help in preparing the manuscript.

Funders	Funder number
United States-Israel Bi-national Sciences Foundation	200295
National Institutes of Health
National Institute of General Medical Sciences	R01GM033279

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10.1016/j.molcel.2004.10.026

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title = "Importin beta: Conducting a much larger cellular symphony",

abstract = "Importin β, once thought to be exclusively a nuclear transport receptor, is emerging as a global regulator of diverse cellular functions. Importin β acts positively in multiple interphase roles: in nuclear import, as a chaperone for highly charged nuclear proteins, and as a potential motor adaptor for movement along microtubules. In contrast, importin β plays a negative regulatory role in mitotic spindle assembly, centrosome dynamics, nuclear membrane formation, and nuclear pore assembly. In most of these, importin β is counteracted by its regulator, Ran-GTP. In light of this, the recent discovery of Ran's involvement in spindle checkpoint control suggested a potential new arena for importin β action, although it is also possible that one of importin β's relatives, the karyopherin family of proteins, manages this checkpoint. Lastly, importin β plays a role in transducing damage signals from the axons of injured neurons back to the cell body.",

author = "Amnon Harel and Forbes, \{Douglass J.\}",

note = "Funding Information: The current papers concerning importin β and the karyopherins number close to a thousand; the authors regret that only a fraction could be cited. The authors were supported by National Institutes of Health grant R01-GM033279 to D.J.F. and a United States-Israel Bi-national Sciences Foundation Grant 200295 to D.F. and Michael Elbaum (Weizmann Institute, Rehovot, Israel). The authors thank Rene Chan, Valerie Delmar, and Corine Lau for help in preparing the manuscript.",

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Importin beta: Conducting a much larger cellular symphony

Abstract

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