Abstract
Schizophrenia patients have abnormal neural responses to salient, infrequent events. We integrated event-related potentials (ERP) and fMRI to examine the contributions of the ventral (salience) and dorsal (sustained) attention networks to this dysfunctional neural activation. Twenty-one schizophrenia patients and 22 healthy controls were assessed in separate sessions with ERP and fMRI during a visual oddball task. Visual P100, N100, and P300 ERP waveforms and fMRI activation were assessed. A joint independent components analysis (jICA) on the ERP and fMRI data were conducted. Patients exhibited reduced P300, but not P100 or N100, amplitudes to targets and reduced fMRI neural activation in both dorsal and ventral attentional networks compared with controls. However, the jICA revealed that the P300 was linked specifically to activation in the ventral (salience) network, including anterior cingulate, anterior insula, and temporal parietal junction, with patients exhibiting significantly lower activation. The P100 and N100 were linked to activation in the dorsal (sustained) network, with no group differences in level of activation. This joint analysis approach revealed the nature of target detection deficits that were not discernable by either imaging methodology alone, highlighting the utility of a multimodal fMRI and ERP approach to understand attentional network deficits in schizophrenia.
Original language | English |
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Article number | 538 |
Pages (from-to) | 95-102 |
Number of pages | 8 |
Journal | NeuroImage: Clinical |
Volume | 9 |
DOIs | |
State | Published - 2015 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2015 Published by Elsevier Ltd.
Funding
This work was supported by a Veterans Affairs (VA) Career Development Award ( Wynn 0001 ) to JKW; VA Merit Review Grant ( I01CX000497 ) and National Institutes of Mental Health ( MH58262 ) to JMF; and National Institutes of Mental Health grants MH43292 and MH065707 to MFG. For generous support, we also thank the Brain Mapping Medical Research Organization , Brain Mapping Support Foundation , Pierson-Lovelace Foundation , The Ahmanson Foundation , William M. and Linda R. Dietel Philanthropic Fund at the Northern Piedmont Community Foundation , Tamkin Foundation , Jennifer Jones-Simon Foundation , Capital Group Companies Charitable Foundation , Robson Family , and Northstar Fund . The funding sources had no role in: the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Funders | Funder number |
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National Institutes of Mental Health | MH58262, MH065707 |
National Institute of Mental Health | R29MH043292 |
Ministry of Patriots and Veterans Affairs | I01CX000497 |
Keywords
- ERP
- Joint ICA
- Oddball
- Salience network
- fMRI