Impaired target detection in schizophrenia and the ventral attentional network: Findings from a joint event-related potential-functional MRI analysis: Target stimulus ERP/fMRI analysis in schizophrenia

Jonathan K. Wynn, Amy M. Jimenez, Brian J. Roach, Alexander Korb, Junghee Lee, William P. Horan, Judith M. Ford, Michael F. Green

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Schizophrenia patients have abnormal neural responses to salient, infrequent events. We integrated event-related potentials (ERP) and fMRI to examine the contributions of the ventral (salience) and dorsal (sustained) attention networks to this dysfunctional neural activation. Twenty-one schizophrenia patients and 22 healthy controls were assessed in separate sessions with ERP and fMRI during a visual oddball task. Visual P100, N100, and P300 ERP waveforms and fMRI activation were assessed. A joint independent components analysis (jICA) on the ERP and fMRI data were conducted. Patients exhibited reduced P300, but not P100 or N100, amplitudes to targets and reduced fMRI neural activation in both dorsal and ventral attentional networks compared with controls. However, the jICA revealed that the P300 was linked specifically to activation in the ventral (salience) network, including anterior cingulate, anterior insula, and temporal parietal junction, with patients exhibiting significantly lower activation. The P100 and N100 were linked to activation in the dorsal (sustained) network, with no group differences in level of activation. This joint analysis approach revealed the nature of target detection deficits that were not discernable by either imaging methodology alone, highlighting the utility of a multimodal fMRI and ERP approach to understand attentional network deficits in schizophrenia.

Original languageEnglish
Article number538
Pages (from-to)95-102
Number of pages8
JournalNeuroImage: Clinical
Volume9
DOIs
StatePublished - 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Published by Elsevier Ltd.

Funding

This work was supported by a Veterans Affairs (VA) Career Development Award ( Wynn 0001 ) to JKW; VA Merit Review Grant ( I01CX000497 ) and National Institutes of Mental Health ( MH58262 ) to JMF; and National Institutes of Mental Health grants MH43292 and MH065707 to MFG. For generous support, we also thank the Brain Mapping Medical Research Organization , Brain Mapping Support Foundation , Pierson-Lovelace Foundation , The Ahmanson Foundation , William M. and Linda R. Dietel Philanthropic Fund at the Northern Piedmont Community Foundation , Tamkin Foundation , Jennifer Jones-Simon Foundation , Capital Group Companies Charitable Foundation , Robson Family , and Northstar Fund . The funding sources had no role in: the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.

FundersFunder number
National Institutes of Mental HealthMH58262, MH065707
National Institute of Mental HealthR29MH043292
Ministry of Patriots and Veterans AffairsI01CX000497

    Keywords

    • ERP
    • Joint ICA
    • Oddball
    • Salience network
    • fMRI

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