Impact of Prior Statin Therapy on 1-year Recurrence and Length of Hospitalization for Acute Idiopathic Pericarditis

William Nseir, Lior Masika, Adi Sharabi-Nov, Raymond Farah

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Statins have anti-inflammatory effects that are independent of their lipid-lowering activity. Objectives: To examine whether prior statins therapy affects the clinical course of the first episode of acute idiopathic pericarditis (AIP) as the 1-year recurrence and length of hospitalization (LOH). Methods: This retrospective study included 148 subjects with first episode AIP admitted between the years 2015 and 2019. Data were collected from two hospitals in Northern Israel. We divided the patients in into two groups: 117 those without statins use and 31 those with prior statins use. We compared age, sex, co-morbidities, drugs, laboratory data, 1-year recurrence, and LOH. Results: The mean age of participants was 43.1 ± 19.4 years. Comparisons between subjects without statins and with prior statins use were made according to age (37.5 ± 16.7 years vs. 64.4 ± 12.7 years, P < 0.01), C-reactive protein (50 ± 40 vs. 48 ± 35 mg/dl, P = 0.9), LOH (5.4 ± 2.85 vs. 8.03 ± 4.92 days, P < 0.01), 1-year recurrence of pericarditis (23 vs. 6 cases, P = 0.95), respectively. Multivariate logistic regression analysis revealed that 1-year recurrence (odds ratio [OR] 0.8, 95% confidence interval [95%CI 0 0.6-1.1, P = 0.41), was not associated with prior statin use, while LOH (OR 2.56, 95%CI 2.08-2.75, P = 0.01) was prolonged with prior statins use in patients with first episode of AID. Conclusions: Prior statins use in patients with the first episode of AIP did not reduce the 1-year recurrence of pericarditis and prolong the LOH.

Original languageEnglish
Pages (from-to)747-751
Number of pages5
JournalIsrael Medical Association Journal
Volume24
Issue number11
StatePublished - Nov 2022

Bibliographical note

Publisher Copyright:
© 2022 Israel Medical Association. All rights reserved.

Keywords

  • 1-year recurrence
  • acute idiopathic pericarditis (AIP)
  • length of hospitalization (LOH)
  • statins

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