Impact of perinatal corticosteroids on neuromotor development and outcome: Review of the literature and new meta-analysis

E. S. Shinwell, S. Eventov-Friedman

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Perinatal corticosteroids are like a double-edged sword. On the one hand, they reduce risk for major morbidity and even mortality; on the other hand, they modify growth and development of body systems, with short- and long-term consequences. The relationship between corticosteroids and neurodevelopmental outcome has been extensively studied in randomized controlled trials, cohort and case-control studies and meta-analyses. In this article we attempt accurately to reflect current clinical equipoise on this issue by reviewing the most recent literature and adding a new meta-analysis on the relationship between postnatal dexamethasone and cerebral palsy and neurodevelopmental impairment.

Original languageEnglish
Pages (from-to)164-170
Number of pages7
JournalSeminars in Fetal and Neonatal Medicine
Volume14
Issue number3
DOIs
StatePublished - Jun 2009
Externally publishedYes

Keywords

  • Bronchopulmonary dysplasia
  • Cerebral palsy
  • Corticosteroids
  • Dexamethasone
  • Preterm infants

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