TY - JOUR
T1 - Impact of perinatal corticosteroids on neuromotor development and outcome
T2 - Review of the literature and new meta-analysis
AU - Shinwell, E. S.
AU - Eventov-Friedman, S.
PY - 2009/6
Y1 - 2009/6
N2 - Perinatal corticosteroids are like a double-edged sword. On the one hand, they reduce risk for major morbidity and even mortality; on the other hand, they modify growth and development of body systems, with short- and long-term consequences. The relationship between corticosteroids and neurodevelopmental outcome has been extensively studied in randomized controlled trials, cohort and case-control studies and meta-analyses. In this article we attempt accurately to reflect current clinical equipoise on this issue by reviewing the most recent literature and adding a new meta-analysis on the relationship between postnatal dexamethasone and cerebral palsy and neurodevelopmental impairment.
AB - Perinatal corticosteroids are like a double-edged sword. On the one hand, they reduce risk for major morbidity and even mortality; on the other hand, they modify growth and development of body systems, with short- and long-term consequences. The relationship between corticosteroids and neurodevelopmental outcome has been extensively studied in randomized controlled trials, cohort and case-control studies and meta-analyses. In this article we attempt accurately to reflect current clinical equipoise on this issue by reviewing the most recent literature and adding a new meta-analysis on the relationship between postnatal dexamethasone and cerebral palsy and neurodevelopmental impairment.
KW - Bronchopulmonary dysplasia
KW - Cerebral palsy
KW - Corticosteroids
KW - Dexamethasone
KW - Preterm infants
UR - http://www.scopus.com/inward/record.url?scp=62849104567&partnerID=8YFLogxK
U2 - 10.1016/j.siny.2008.12.001
DO - 10.1016/j.siny.2008.12.001
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C2 - 19109083
AN - SCOPUS:62849104567
SN - 1744-165X
VL - 14
SP - 164
EP - 170
JO - Seminars in Fetal and Neonatal Medicine
JF - Seminars in Fetal and Neonatal Medicine
IS - 3
ER -