Impact of gastric banding on plasma ghrelin, growth hormone, cortisol, DHEA and DHEA-S levels

Edward Ram, Tali Vishne, Dror Diker, Irit Gal-Ad, Rachel Maayan, Igor Lerner, Zeev Dreznik, Dan Seror, Pnina Vardi, Abraham Weizman

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Background: Several endocrine abnormalities are reported in obesity. Some are considered as causative factors, whereas others are considered to be secondary effects of obesity. In the current study, we explored the changes in cortisol, growth hormone (GH), DHEA, DHEA-S and GH releasing hormone (ghrelin) plasma levels in morbidly obese subjects who lost abundant weight following laparoscopic adjustable gastric banding (LAGB). Methods: 12 morbidly obese adult patients (15 females), age 21-56 years with BMI 46.0±4.4 kg/cm 2, were studied. Blood samples were collected before, 6 and 14 months after LAGB. The levels of DHEA, DHEA-S, cortisol, GH, and ghrelin were determined by commercial kits. Statistical analysis was based on one-way repeated measures ANOVA, followed by Student-Newman-Keuls post-hoc test. Results: Mean BMI reduced significantly along the study course (P=.000). Cortisol plasma levels significantly decreased 6 months after surgery (from 541.4±242.4 nM to 382.4±142.1 nM, P=.004), but did not change further after 14 months (460.2±244.9 nM), despite further reduction in BMI (P=.050). GH constantly increased throughout the study from 0.076±0.149ng/ml, to 0.410±0.509 ng/ml at 6 months (NS), to 1.224±1.738 ng/ml at 14 months after surgery (P=.001). DHEA, DHEA-S and ghrelin plasma levels remained stable throughout the study. Conclusions: GH levels showed a persistent increase during the 14 months following LAGB in association with the weight loss, while a transient decrease in cortisol levels occurred at the 6-months time-point. In contrast, ghrelin, DHEA and DHEA-S were not altered after surgery. The association between GH and cortisol secretion and surgical- and nonsurgical-induced weight reduction merits further investigation.

Original languageEnglish
Pages (from-to)1118-1123
Number of pages6
JournalObesity Surgery
Issue number8
StatePublished - Sep 2005
Externally publishedYes


  • Cortisol
  • DHEA
  • DHEA-S
  • GH
  • Ghrelin
  • Laparoscopic gastric banding
  • Morbid obesity
  • Weight loss


Dive into the research topics of 'Impact of gastric banding on plasma ghrelin, growth hormone, cortisol, DHEA and DHEA-S levels'. Together they form a unique fingerprint.

Cite this