Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 MRNA COVID-19 vaccine: Real-world evidence from healthcare workers, Israel, December 2020 to January 2021

Kamal Abu Jabal; Hila Ben-Amram; Karine Beiruti; Yunis Batheesh; Christian Sussan; Salman Zarka; Michael Edelstein

doi:10.2807/1560-7917.ES.2021.26.6.2100096

Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 MRNA COVID-19 vaccine: Real-world evidence from healthcare workers, Israel, December 2020 to January 2021

Kamal Abu Jabal
, Hila Ben-Amram
, Karine Beiruti
, Yunis Batheesh
, Christian Sussan
, Salman Zarka
, Michael Edelstein

Bar-Ilan University - Azrieli Faculty of Medicine

Ziv Medical Centre

Research output: Contribution to journal › Article › peer-review

225 Scopus citations

Abstract

The BNT162b2 mRNA COVID-19 vaccine showed high efficacy in clinical trials but observational data from populations not included in trials are needed. We describe immunogenicity 21 days post-dose 1 among 514 Israeli healthcare workers by age, ethnicity, sex and prior COVID-19 infection. Immunogenicity was similar by ethnicity and sex but decreased with age. Those with prior infection had antibody titres one magnitude order higher than naïve individuals regardless of the presence of detectable IgG antibodies pre-vaccination.

Original language	English
Journal	Eurosurveillance
Volume	26
Issue number	6
DOIs	https://doi.org/10.2807/1560-7917.ES.2021.26.6.2100096
State	Published - Feb 2021

Bibliographical note

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© 2021 European Centre for Disease Prevention and Control (ECDC). All rights reserved.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Jabal, K. A., Ben-Amram, H., Beiruti, K., Batheesh, Y., Sussan, C., Zarka, S., & Edelstein, M. (2021). Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 MRNA COVID-19 vaccine: Real-world evidence from healthcare workers, Israel, December 2020 to January 2021. Eurosurveillance, 26(6). https://doi.org/10.2807/1560-7917.ES.2021.26.6.2100096

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abstract = "The BNT162b2 mRNA COVID-19 vaccine showed high efficacy in clinical trials but observational data from populations not included in trials are needed. We describe immunogenicity 21 days post-dose 1 among 514 Israeli healthcare workers by age, ethnicity, sex and prior COVID-19 infection. Immunogenicity was similar by ethnicity and sex but decreased with age. Those with prior infection had antibody titres one magnitude order higher than na{\"i}ve individuals regardless of the presence of detectable IgG antibodies pre-vaccination.",

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Jabal, KA, Ben-Amram, H, Beiruti, K, Batheesh, Y, Sussan, C, Zarka, S & Edelstein, M 2021, 'Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 MRNA COVID-19 vaccine: Real-world evidence from healthcare workers, Israel, December 2020 to January 2021', Eurosurveillance, vol. 26, no. 6. https://doi.org/10.2807/1560-7917.ES.2021.26.6.2100096

Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 MRNA COVID-19 vaccine: Real-world evidence from healthcare workers, Israel, December 2020 to January 2021. / Jabal, Kamal Abu; Ben-Amram, Hila; Beiruti, Karine et al.
In: Eurosurveillance, Vol. 26, No. 6, 02.2021.

Research output: Contribution to journal › Article › peer-review

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AU - Jabal, Kamal Abu

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AU - Beiruti, Karine

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AB - The BNT162b2 mRNA COVID-19 vaccine showed high efficacy in clinical trials but observational data from populations not included in trials are needed. We describe immunogenicity 21 days post-dose 1 among 514 Israeli healthcare workers by age, ethnicity, sex and prior COVID-19 infection. Immunogenicity was similar by ethnicity and sex but decreased with age. Those with prior infection had antibody titres one magnitude order higher than naïve individuals regardless of the presence of detectable IgG antibodies pre-vaccination.

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Jabal KA, Ben-Amram H, Beiruti K, Batheesh Y, Sussan C, Zarka S et al. Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 MRNA COVID-19 vaccine: Real-world evidence from healthcare workers, Israel, December 2020 to January 2021. Eurosurveillance. 2021 Feb;26(6). doi: 10.2807/1560-7917.ES.2021.26.6.2100096

Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 MRNA COVID-19 vaccine: Real-world evidence from healthcare workers, Israel, December 2020 to January 2021

Abstract

Bibliographical note

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