Immunology of Follicle-Stimulating Hormone and Luteinizing Hormone

B. Lunenfeld; Aliza Eshkol

doi:10.1016/S0083-6729(08)61126-7

Immunology of Follicle-Stimulating Hormone and Luteinizing Hormone

B. Lunenfeld
, Aliza Eshkol

Department of Chemistry

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The status of separation of pituitary and urinary gonadotropins and the degree of purity of the preparations available today has been summarized. Although neither FSH nor LH exist in a pure form, they have been used extensively in immunochemical studies. It was shown that their absolute purity is not as crucial when used for immunization and as reference material as when employed as the antigen reagent adsorbed to solid particles or as a labeled tracer. The importance of employing standards of similar origin as the test samples has been emphasized. Extensive immunological investigations based on comparative studies of hormone-antihormone interactions in in vivo and in vitro systems indicate that although gonadotropins of pituitary and urinary (menopausal) extracts are physiologically similar, they probably differ antigenically and thus should not be used interchangably as standards.

Original language	English
Pages (from-to)	131-197
Number of pages	67
Journal	Vitamins and Hormones
Volume	27
Issue number	C
DOIs	https://doi.org/10.1016/S0083-6729(08)61126-7
State	Published - 1 Jan 1970

Bibliographical note

Funding Information:
ACKNOWLEDGMENTS This review has been compiled in collaboration with Dr. A. G. Shapiro, of Cornell University, Ithaca, New York, 1961969 Post doctorate Fellow at the Institute of Endocrinology, Tel-Hashomer Governnient Hospital, Israel. The authors are indebted to Dr. John A. Loraine, who has read the manuscript and made many useful suggestions. We also wish to thank Mrs. B. Kate for typing this chapter. This work was supported in part by Ford Foundation Grant No. 67-470.

Funding

ACKNOWLEDGMENTS This review has been compiled in collaboration with Dr. A. G. Shapiro, of Cornell University, Ithaca, New York, 1961969 Post doctorate Fellow at the Institute of Endocrinology, Tel-Hashomer Governnient Hospital, Israel. The authors are indebted to Dr. John A. Loraine, who has read the manuscript and made many useful suggestions. We also wish to thank Mrs. B. Kate for typing this chapter. This work was supported in part by Ford Foundation Grant No. 67-470.

Funders	Funder number
Ford Foundation	67-470

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10.1016/S0083-6729(08)61126-7

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title = "Immunology of Follicle-Stimulating Hormone and Luteinizing Hormone",

abstract = "The status of separation of pituitary and urinary gonadotropins and the degree of purity of the preparations available today has been summarized. Although neither FSH nor LH exist in a pure form, they have been used extensively in immunochemical studies. It was shown that their absolute purity is not as crucial when used for immunization and as reference material as when employed as the antigen reagent adsorbed to solid particles or as a labeled tracer. The importance of employing standards of similar origin as the test samples has been emphasized. Extensive immunological investigations based on comparative studies of hormone-antihormone interactions in in vivo and in vitro systems indicate that although gonadotropins of pituitary and urinary (menopausal) extracts are physiologically similar, they probably differ antigenically and thus should not be used interchangably as standards.",

author = "B. Lunenfeld and Aliza Eshkol",

note = "Funding Information: ACKNOWLEDGMENTS This review has been compiled in collaboration with Dr. A. G. Shapiro, of Cornell University, Ithaca, New York, 1961969 Post doctorate Fellow at the Institute of Endocrinology, Tel-Hashomer Governnient Hospital, Israel. The authors are indebted to Dr. John A. Loraine, who has read the manuscript and made many useful suggestions. We also wish to thank Mrs. B. Kate for typing this chapter. This work was supported in part by Ford Foundation Grant No. 67-470.",

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doi = "10.1016/S0083-6729(08)61126-7",

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N2 - The status of separation of pituitary and urinary gonadotropins and the degree of purity of the preparations available today has been summarized. Although neither FSH nor LH exist in a pure form, they have been used extensively in immunochemical studies. It was shown that their absolute purity is not as crucial when used for immunization and as reference material as when employed as the antigen reagent adsorbed to solid particles or as a labeled tracer. The importance of employing standards of similar origin as the test samples has been emphasized. Extensive immunological investigations based on comparative studies of hormone-antihormone interactions in in vivo and in vitro systems indicate that although gonadotropins of pituitary and urinary (menopausal) extracts are physiologically similar, they probably differ antigenically and thus should not be used interchangably as standards.

AB - The status of separation of pituitary and urinary gonadotropins and the degree of purity of the preparations available today has been summarized. Although neither FSH nor LH exist in a pure form, they have been used extensively in immunochemical studies. It was shown that their absolute purity is not as crucial when used for immunization and as reference material as when employed as the antigen reagent adsorbed to solid particles or as a labeled tracer. The importance of employing standards of similar origin as the test samples has been emphasized. Extensive immunological investigations based on comparative studies of hormone-antihormone interactions in in vivo and in vitro systems indicate that although gonadotropins of pituitary and urinary (menopausal) extracts are physiologically similar, they probably differ antigenically and thus should not be used interchangably as standards.

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Immunology of Follicle-Stimulating Hormone and Luteinizing Hormone

Abstract

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