Immunogenicity of aeromonas salmonicida a-protein in goldfish (Carassius Auratus L.)

M. Sinyakov, M. Dror, S. Margel, R. R. Avtalion

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Antigenicity of the surface A-layer protein of an atypical Aeromonas salmonicida strain was tested in goldfish following immunization with various A-protein (AP) antigenic preparations (soluble form, alum-precipitated, conjugated with polyacrolein nanoparticles, or bacterin). ELISA revealed innate specific anti-AP antibody activity in all fish on day 0, while no significant antibody enhancement was seen on days 21 or 42 following the primary immunization. A second stimulation with soluble AP resulted in a clear response in groups primed with bacterin and alum-precipitated AP but no response in those primed with soluble AP or AP-nanoparticles conjugate. The implication of these results for vaccine design is discussed.

Original languageEnglish
Pages (from-to)110-114
Number of pages5
JournalIsraeli Journal of Aquaculture - Bamidgeh
Issue number3-4
StatePublished - 2001


  • A-layer protein immunogenicity
  • Aeromonas salmonicida
  • Goldfish


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