Immunodeficiency and other clinical immunology. Nedocromil sodium inhibits T-cell function in vitro and in vivo

Yoseph A. Mekori, Dana Baram, Arnon Goldberg, Rami Hershkoviz, Tamar Reshef, Devora Sredni

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11 Scopus citations


Nedocromil sodium, a topical antiinflammatory agent recommended as a prophylactic regimen for asthma, is known to inhibit both allergic and nonallergic inflammatory processes in which an essential role for T cells has been implicated. Therefore the direct effects of this drug on several aspects of T-cell activity were analyzed in the present study. By using murine lymphocytes we found that NS at concentrations of 10-8 to 10-6 mollL inhibited the mitogen- or antigen-induced proliferative responses of these cells. It is interesting to note that higher concentratrions were ineffective. Preincubation of immune lymph node cells from contact sensitized mice with the drug abrogated their ability to transfer contact sensitivity to naive recipients, an effect that was found to be specific for the treated cells. Nedocromil sodium also interfered with the mitogen-induced interleukin-2 and tumor necrosis factor production by T cells and with their ability to adhere to the bound protein components of the extracellular matrix laminin and fibronectin. All these effects may be attributed to the inhibition of the increase of cytosolic calcium, which accompanies the early phase of T-cell activation and which is an essential step in inducing the aforementioned phenomena.

Original languageEnglish
Pages (from-to)817-824
Number of pages8
JournalJournal of Allergy and Clinical Immunology
Issue number3
StatePublished - Mar 1993
Externally publishedYes

Bibliographical note

Funding Information:
From the Allergy-Immunology Unit” and the Department of Med-icine “B”,b Meir General Hospital, Kfar Saba, and the Sackler School of Medicine, Tel-Aviv University, Israel. Supported in part by a grant from tbe Israel Ministry of Health (to Y.A.M.). Received for publication July 21, 1992. Revised Sept. 30, 1992. Accepted for publication Oct. 5, 1992. Reprint requests: Y. A. Mekori, MD, Department of Medicine “B”, Meir General Hospital, Kfar Saba 44281, Israel. Copyright 0 1993 Mosby-Year Book, Inc. 0091-6749/93 $1.00 + .I0 l/1/43219


  • IL-2
  • Nedocromil sodium
  • T lymphocytes
  • TNF-α
  • contact sensitivity
  • extracellular matrix


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