Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome

T21RS COVID-19 Initiative

doi:10.3389/fimmu.2021.621440

Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome

T21RS COVID-19 Initiative

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

The risk of severe outcomes following respiratory tract infections is significantly increased in individuals over 60 years, especially in those with chronic medical conditions, i.e., hypertension, diabetes, cardiovascular disease, dementia, chronic respiratory disease, and cancer. Down Syndrome (DS), the most prevalent intellectual disability, is caused by trisomy-21 in ~1:750 live births worldwide. Over the past few decades, a substantial body of evidence has accumulated, pointing at the occurrence of alterations, impairments, and subsequently dysfunction of the various components of the immune system in individuals with DS. This associates with increased vulnerability to respiratory tract infections in this population, such as the influenza virus, respiratory syncytial virus, SARS-CoV-2 (COVID-19), and bacterial pneumonias. To emphasize this link, here we comprehensively review the immunobiology of DS and its contribution to higher susceptibility to severe illness and mortality from respiratory tract infections.

Original language	English
Article number	621440
Journal	Frontiers in Immunology
Volume	12
DOIs	https://doi.org/10.3389/fimmu.2021.621440
State	Published - 25 Jun 2021

Bibliographical note

Publisher Copyright:
© Copyright © 2021 Illouz, Biragyn, Iulita, Flores-Aguilar, Dierssen, De Toma, Antonarakis, Yu, Herault, Potier, Botté, Roper, Sredni, London, Mobley, Strydom and Okun.

Funding

This research was supported in part by the Clore Israel Foundation and the Intramural Research Program of the National Institute on Aging. We thank Yael Laure for the thorough editing of this manuscript.

Funders	Funder number
Clore Israel Foundation
National Institute on Aging	ZIAAG000444

Keywords

COVID-19
Down syndrome
hospitalization
immune dysregulation
interferon
respiratory tract infections

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/fimmu.2021.621440

Cite this

@article{b0b5ae71e32a4d46bd6da42a6346d30d,

title = "Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome",

abstract = "The risk of severe outcomes following respiratory tract infections is significantly increased in individuals over 60 years, especially in those with chronic medical conditions, i.e., hypertension, diabetes, cardiovascular disease, dementia, chronic respiratory disease, and cancer. Down Syndrome (DS), the most prevalent intellectual disability, is caused by trisomy-21 in ~1:750 live births worldwide. Over the past few decades, a substantial body of evidence has accumulated, pointing at the occurrence of alterations, impairments, and subsequently dysfunction of the various components of the immune system in individuals with DS. This associates with increased vulnerability to respiratory tract infections in this population, such as the influenza virus, respiratory syncytial virus, SARS-CoV-2 (COVID-19), and bacterial pneumonias. To emphasize this link, here we comprehensively review the immunobiology of DS and its contribution to higher susceptibility to severe illness and mortality from respiratory tract infections.",

keywords = "COVID-19, Down syndrome, hospitalization, immune dysregulation, interferon, respiratory tract infections",

author = "{T21RS COVID-19 Initiative} and Tomer Illouz and Arya Biragyn and Iulita, {Maria Florencia} and Lisi Flores-Aguilar and Mara Dierssen and {De Toma}, Ilario and Antonarakis, {Stylianos E.} and Eugene Yu and Yann Herault and Potier, {Marie Claude} and Alexandra Bott{\'e} and Randall Roper and Benjamin Sredni and Jacqueline London and William Mobley and Andre Strydom and Eitan Okun",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Illouz, Biragyn, Iulita, Flores-Aguilar, Dierssen, De Toma, Antonarakis, Yu, Herault, Potier, Bott{\'e}, Roper, Sredni, London, Mobley, Strydom and Okun.",

year = "2021",

month = jun,

day = "25",

doi = "10.3389/fimmu.2021.621440",

language = "אנגלית",

volume = "12",

journal = "Frontiers in Immunology",

issn = "1664-3224",

publisher = "Frontiers Media SA",

}

TY - JOUR

T1 - Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome

AU - T21RS COVID-19 Initiative

AU - Illouz, Tomer

AU - Biragyn, Arya

AU - Iulita, Maria Florencia

AU - Flores-Aguilar, Lisi

AU - Dierssen, Mara

AU - De Toma, Ilario

AU - Antonarakis, Stylianos E.

AU - Yu, Eugene

AU - Herault, Yann

AU - Potier, Marie Claude

AU - Botté, Alexandra

AU - Roper, Randall

AU - Sredni, Benjamin

AU - London, Jacqueline

AU - Mobley, William

AU - Strydom, Andre

AU - Okun, Eitan

PY - 2021/6/25

Y1 - 2021/6/25

N2 - The risk of severe outcomes following respiratory tract infections is significantly increased in individuals over 60 years, especially in those with chronic medical conditions, i.e., hypertension, diabetes, cardiovascular disease, dementia, chronic respiratory disease, and cancer. Down Syndrome (DS), the most prevalent intellectual disability, is caused by trisomy-21 in ~1:750 live births worldwide. Over the past few decades, a substantial body of evidence has accumulated, pointing at the occurrence of alterations, impairments, and subsequently dysfunction of the various components of the immune system in individuals with DS. This associates with increased vulnerability to respiratory tract infections in this population, such as the influenza virus, respiratory syncytial virus, SARS-CoV-2 (COVID-19), and bacterial pneumonias. To emphasize this link, here we comprehensively review the immunobiology of DS and its contribution to higher susceptibility to severe illness and mortality from respiratory tract infections.

AB - The risk of severe outcomes following respiratory tract infections is significantly increased in individuals over 60 years, especially in those with chronic medical conditions, i.e., hypertension, diabetes, cardiovascular disease, dementia, chronic respiratory disease, and cancer. Down Syndrome (DS), the most prevalent intellectual disability, is caused by trisomy-21 in ~1:750 live births worldwide. Over the past few decades, a substantial body of evidence has accumulated, pointing at the occurrence of alterations, impairments, and subsequently dysfunction of the various components of the immune system in individuals with DS. This associates with increased vulnerability to respiratory tract infections in this population, such as the influenza virus, respiratory syncytial virus, SARS-CoV-2 (COVID-19), and bacterial pneumonias. To emphasize this link, here we comprehensively review the immunobiology of DS and its contribution to higher susceptibility to severe illness and mortality from respiratory tract infections.

KW - COVID-19

KW - Down syndrome

KW - hospitalization

KW - immune dysregulation

KW - interferon

KW - respiratory tract infections

UR - http://www.scopus.com/inward/record.url?scp=85109665538&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2021.621440

DO - 10.3389/fimmu.2021.621440

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???

C2 - 34248930

AN - SCOPUS:85109665538

SN - 1664-3224

VL - 12

JO - Frontiers in Immunology

JF - Frontiers in Immunology

M1 - 621440

ER -

Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this