Imidazole and trifluoroethanol as efficient and mild reagents for destruction of excess di-tert-butyl dicarbonate [(BOC)2O]1

Y. Basel, A. Hassner

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Mild and efficient procedures employing inexpensive reagents (imidazole or trifluoroethanol) for the removal of excess (BOC)2O, usually used during NH or OH protection at room temperature, are described. The use of polymer-based DMAP with or without TFE was also found to be attractive.

Original languageEnglish
Pages (from-to)550-552
Number of pages3
JournalSynthesis
Issue number4
StatePublished - 2001

Keywords

  • (BOC)O excess
  • DMAP
  • Imidazole (Im)
  • PolyDMAP
  • Trifluoroethanol (TFE)

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