IL-27 Acts on DCs to Suppress CNS Autoimmunity by Inducing CD39 Expression

I Mascanfroni; A Yeste; S Vieira; E Burns; B Patel; I Sloma; Y Wu; L Mayo; R Ben-hamo; S Efroni; V Kuchroo

doi:10.1016/j.jneuroim.2014.08.236

IL-27 Acts on DCs to Suppress CNS Autoimmunity by Inducing CD39 Expression

I Mascanfroni, A Yeste, S Vieira, E Burns, B Patel, I Sloma, Y Wu, L Mayo, R Ben-hamo, S Efroni, V Kuchroo

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Dendritic cells (DCs) control the balance between effector T cells and regulatory T cells in vivo. Hence, the study of DCs might identify mechanisms of disease pathogenesis and guide new therapeutic approaches for disorders mediated by the immune system. We found that interleukin 27 (IL-27) signaling in mouse DCs limited the generation of effector cells of the TH1 and TH17 subsets of helper T cells and the development of experimental autoimmune encephalomyelitis (EAE). The effects of IL-27 were mediated at least in part through induction of the immunoregulatory molecule CD39 in DCs.

Original language	American English
Pages (from-to)	88-88
Number of pages	1
Journal	Journal of Neuroimmunology
Volume	275
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2014.08.236
State	Published - 15 Oct 2014

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10.1016/j.jneuroim.2014.08.236

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title = "IL-27 Acts on DCs to Suppress CNS Autoimmunity by Inducing CD39 Expression",

abstract = "Dendritic cells (DCs) control the balance between effector T cells and regulatory T cells in vivo. Hence, the study of DCs might identify mechanisms of disease pathogenesis and guide new therapeutic approaches for disorders mediated by the immune system. We found that interleukin 27 (IL-27) signaling in mouse DCs limited the generation of effector cells of the TH1 and TH17 subsets of helper T cells and the development of experimental autoimmune encephalomyelitis (EAE). The effects of IL-27 were mediated at least in part through induction of the immunoregulatory molecule CD39 in DCs.",

author = "I Mascanfroni and A Yeste and S Vieira and E Burns and B Patel and I Sloma and Y Wu and L Mayo and R Ben-hamo and S Efroni and V Kuchroo",

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AU - Mascanfroni, I

AU - Yeste, A

AU - Vieira, S

AU - Burns, E

AU - Patel, B

AU - Sloma, I

AU - Wu, Y

AU - Mayo, L

AU - Ben-hamo, R

AU - Efroni, S

AU - Kuchroo, V

PY - 2014/10/15

Y1 - 2014/10/15

N2 - Dendritic cells (DCs) control the balance between effector T cells and regulatory T cells in vivo. Hence, the study of DCs might identify mechanisms of disease pathogenesis and guide new therapeutic approaches for disorders mediated by the immune system. We found that interleukin 27 (IL-27) signaling in mouse DCs limited the generation of effector cells of the TH1 and TH17 subsets of helper T cells and the development of experimental autoimmune encephalomyelitis (EAE). The effects of IL-27 were mediated at least in part through induction of the immunoregulatory molecule CD39 in DCs.

AB - Dendritic cells (DCs) control the balance between effector T cells and regulatory T cells in vivo. Hence, the study of DCs might identify mechanisms of disease pathogenesis and guide new therapeutic approaches for disorders mediated by the immune system. We found that interleukin 27 (IL-27) signaling in mouse DCs limited the generation of effector cells of the TH1 and TH17 subsets of helper T cells and the development of experimental autoimmune encephalomyelitis (EAE). The effects of IL-27 were mediated at least in part through induction of the immunoregulatory molecule CD39 in DCs.

UR - https://www.mendeley.com/catalogue/e762f820-0326-3ff4-899c-a260eb437004/

U2 - 10.1016/j.jneuroim.2014.08.236

DO - 10.1016/j.jneuroim.2014.08.236

M3 - Article

SN - 0165-5728

VL - 275

SP - 88

EP - 88

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

IL-27 Acts on DCs to Suppress CNS Autoimmunity by Inducing CD39 Expression

Abstract

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