Identification of recurrent regulated alternative splicing events across human solid tumors

Miri Danan-Gotthold, Regina Golan-Gerstl, Eli Eisenberg, Keren Meir, Rotem Karni, Erez Y. Levanon

Research output: Contribution to journalArticlepeer-review

121 Scopus citations

Abstract

Cancer is a complex disease that involves aberrant gene expression regulation. Discriminating the modified expression patterns driving tumor biology from the many that have no or little contribution is important for understanding cancer molecular basis. Recurrent deregulation patterns observed in multiple cancer types are enriched for such driver events. Here, we studied splicing alterations in hundreds of matched tumor and normal RNA-seq samples of eight solid cancer types. We found hundreds of cassette exons for which splicing was altered in multiple cancer types and identified a set of highly frequent altered splicing events. Specific splicing regulators, including RBFOX2, MBNL1/2 and QKI, appear to account for many splicing alteration events in multiple cancer types. Together, our results provide a first global analysis of regulated splicing alterations in cancer and identify common events with a potential causative role in solid tumor development.

Original languageEnglish
Pages (from-to)5130-5144
Number of pages15
JournalNucleic Acids Research
Volume43
Issue number10
DOIs
StatePublished - 26 May 2015

Bibliographical note

Publisher Copyright:
© 2015 The Author(s). Published by Oxford University Press on behalf of Nucleic Acids Research.

Funding

FundersFunder number
European Research Council
Seventh Framework Programme311257

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