Abstract
The modern lifestyle requires less physical activity and skills during our daily routine, leading to multiple pathologies related to physical disabilities and energy accessibility. Thus, exploring the mechanisms underlying the metabolic regulation of exercise is crucial. Here, we characterized the effect of forced and voluntary endurance exercises on three key metabolic signaling pathways, sirtuins, AMPK, and mTOR, across several metabolic tissues in mice: brain, muscles, and liver. Both voluntary and forced exercises induced AMPK with higher intensity in the first. The comparison between those metabolic tissues revealed that the hypothalamus and the hippocampus, two brain parts, showed different metabolic signaling activities. Strikingly, despite the major differences in the physiology of muscles and hypothalamic tissues, the hypothalamus replicates the metabolic response of the muscle in response to physical exercise. Specifically, muscles and hypothalamic tissues showed an increase and a decrease in AMPK and mTOR signaling, respectively. Overall, this study reveals new insight into the relation between the hypothalamus and muscles, which enhances the coordination within the muscle–brain axis and potentially improves the systemic response to physical activity performance and delaying health inactivity disorders.
Original language | English |
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Article number | 897005 |
Journal | Frontiers in Neuroscience |
Volume | 16 |
DOIs | |
State | Published - 19 Jul 2022 |
Bibliographical note
Publisher Copyright:Copyright © 2022 Katz, Gonen, Shahar, Roichman, Lerrer and Cohen.
Funding
This study was supported by the Israel Science Foundation (890/21 and 777/16), I-CORE (41/11), the U. S. Israel Binational Science Foundation (BSF, 2019312), and the SAGOL Center of Healthy Human Longevity.
Funders | Funder number |
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United States - Israel Binational Science Foundation | |
United States-Israel Binational Science Foundation | 2019312 |
Israel Science Foundation | 777/16, 890/21 |
Israeli Centers for Research Excellence | 41/11 |
Keywords
- exercise
- hippocampus
- hypothalamus
- metabolic pathways
- muscle