TY - JOUR
T1 - Hypoglycemic and hypolipidemic activity of Pongamia pinnata (Linn.) pierre in Streptozotocin-induced diabetic rats
AU - Kumar, P.
AU - Semalty, A.
AU - Mir, S. R.
AU - Ali, M.
AU - Amin, S.
PY - 2010
Y1 - 2010
N2 - The plant Pongamia pinnata (Linn.) Pierre of family Leguminosae sub-family Papilioanaceae was evaluated for its hypoglycemic and hypolipidemic activity in streptozotocin induced diabetic rats. A new difuranoflavonone Compound PP (named Pongamiaflavonol), isolated from methanlolic extract of P. pinnata pods by column chromatography, was also studied for the activity. It was observed that after 14 days of treatment blood glucose level was reduced by 66.34, 54.82, 63.62 and 67.48 % with Std. Glibenclamiade 3 mg kg-1), P. pinnata pods (300 mg kg-1), P. pinnata flowers (300 mg kg-1) and PP (100 mg kg-1), respectively. The lipid profile was also studied and was found to be normalized significantly by both the flowers and pods extracts of P. pinnata and compound PP.
AB - The plant Pongamia pinnata (Linn.) Pierre of family Leguminosae sub-family Papilioanaceae was evaluated for its hypoglycemic and hypolipidemic activity in streptozotocin induced diabetic rats. A new difuranoflavonone Compound PP (named Pongamiaflavonol), isolated from methanlolic extract of P. pinnata pods by column chromatography, was also studied for the activity. It was observed that after 14 days of treatment blood glucose level was reduced by 66.34, 54.82, 63.62 and 67.48 % with Std. Glibenclamiade 3 mg kg-1), P. pinnata pods (300 mg kg-1), P. pinnata flowers (300 mg kg-1) and PP (100 mg kg-1), respectively. The lipid profile was also studied and was found to be normalized significantly by both the flowers and pods extracts of P. pinnata and compound PP.
KW - Antidiabetic activity
KW - Hypolipidemic
KW - Karanja
KW - Pongamia pinnata
KW - Streptozotocin
UR - http://www.scopus.com/inward/record.url?scp=77955705418&partnerID=8YFLogxK
U2 - 10.3923/ijp.2010.738.743
DO - 10.3923/ijp.2010.738.743
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:77955705418
SN - 1811-7775
VL - 6
SP - 738
EP - 743
JO - International Journal of Pharmacology
JF - International Journal of Pharmacology
IS - 5
ER -
