Hypertonic glucose preloads act preabsorptively to decrease intake in rats on postnatal day 18

Aron Weller, Ludmila Tsitolovskya, Gerard P. Smith

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4 Scopus citations

Abstract

To determine if preloads of glucose act preabsorptively or postabsorptively to inhibit intake, 18-day-old rat pups were deprived for 24 h and then provided with sweet milk during a 30-min independent ingestion test. Five minutes before the test, gastric preloads (5% body weight, BW) or intraperitoneal injections (4 ml/kg BW) of isotonic, hypotonic, and hypertonic solutions of glucose or 2-deoxy-D-glucose (2-DG) were administered. There were two major results: First, preloads of 20% glucose decreased intake much more than intraperitoneal injections of 20% glucose. Second, a preload of 20% 2-DG, which decreases, rather than increases glucose utilization, was as effective as a preload of 20% glucose in decreasing intake. These results are consistent with a preabsorptive osmotic mechanism, but not with a postabsorptive metabolic mechanism, for mediating most, if not all, of the inhibition of intake 5 min after preloads of 20% glucose in rats on postnatal day 18 (P18).

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalPhysiology and Behavior
Volume72
Issue number1-2
DOIs
StatePublished - Jan 2001

Bibliographical note

Funding Information:
The authors thank Ofra Schwartz for technical assistance and Laurel Torres for processing the manuscript. Dr. Tsitolovska was supported by a fellowship from the Israel Ministry of Absorption. Dr. Smith was supported by MH40010.

Funding

The authors thank Ofra Schwartz for technical assistance and Laurel Torres for processing the manuscript. Dr. Tsitolovska was supported by a fellowship from the Israel Ministry of Absorption. Dr. Smith was supported by MH40010.

FundersFunder number
Israel Ministry of Absorption
National Institute of Mental HealthR01MH040010

    Keywords

    • 2-Deoxy-D-glucose
    • Gastric preloads
    • Independent ingestion
    • Ontogeny of food intake
    • Osmotic load
    • Satiety

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