Hypertonic glucose preloads act preabsorptively to decrease intake in rats on postnatal day 18

Aron Weller, Ludmila Tsitolovskya, Gerard P. Smith

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To determine if preloads of glucose act preabsorptively or postabsorptively to inhibit intake, 18-day-old rat pups were deprived for 24 h and then provided with sweet milk during a 30-min independent ingestion test. Five minutes before the test, gastric preloads (5% body weight, BW) or intraperitoneal injections (4 ml/kg BW) of isotonic, hypotonic, and hypertonic solutions of glucose or 2-deoxy-D-glucose (2-DG) were administered. There were two major results: First, preloads of 20% glucose decreased intake much more than intraperitoneal injections of 20% glucose. Second, a preload of 20% 2-DG, which decreases, rather than increases glucose utilization, was as effective as a preload of 20% glucose in decreasing intake. These results are consistent with a preabsorptive osmotic mechanism, but not with a postabsorptive metabolic mechanism, for mediating most, if not all, of the inhibition of intake 5 min after preloads of 20% glucose in rats on postnatal day 18 (P18).

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalPhysiology and Behavior
Issue number1-2
StatePublished - 2001

Bibliographical note

Funding Information:
The authors thank Ofra Schwartz for technical assistance and Laurel Torres for processing the manuscript. Dr. Tsitolovska was supported by a fellowship from the Israel Ministry of Absorption. Dr. Smith was supported by MH40010.


  • 2-Deoxy-D-glucose
  • Gastric preloads
  • Independent ingestion
  • Ontogeny of food intake
  • Osmotic load
  • Satiety


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