Hypertension-misattributed kidney disease in African Americans

Karl L. Skorecki, Walter G. Wasser

Research output: Contribution to journalComment/debate

28 Scopus citations


Lipkowitz et al. extend the African American Study of Kidney Disease and Hypertension to the level of genetic epidemiology, in a case-control study design. Analysis of genotypes at the APOL1 kidney disease risk region supports a paradigm shift in which genetic risk is proximate to both kidney disease and hypertension. The findings mandate urgency in clarifying mechanisms whereby APOL1 region risk variants interact with environmental triggers to cause progressive kidney disease accompanied by dangerous hypertension.

Original languageEnglish
Pages (from-to)6-9
Number of pages4
JournalKidney International
Issue number1
StatePublished - Jan 2013
Externally publishedYes


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