Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients

Sigal Tal, Amir Hadanny, Efrat Sasson, Gil Suzin, Shai Efrati

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Background: Recent clinical studies in stroke and traumatic brain injury (TBI) victims suffering chronic neurological injury present evidence that hyperbaric oxygen therapy (HBOT) can induce neuroplasticity. Objective: To assess the neurotherapeutic effect of HBOT on prolonged post-concussion syndrome (PPCS) due to TBI, using brain microstructure imaging. Methods: Fifteen patients afflicted with PPCS were treated with 60 daily HBOT sessions. Imaging evaluation was performed using Dynamic Susceptibility Contrast-Enhanced (DSC) and Diffusion Tensor Imaging (DTI) MR sequences. Cognitive evaluation was performed by an objective computerized battery (NeuroTrax). Results: HBOT was initiated 6 months to 27 years (10.3 ± 3.2 years) from injury. After HBOT, DTI analysis showed significantly increased fractional anisotropy values and decreased mean diffusivity in both white and gray matter structures. In addition, the cerebral blood flow and volume were increased significantly. Clinically, HBOT induced significant improvement in the memory, executive functions, information processing speed and global cognitive scores. Conclusions: The mechanisms by which HBOT induces brain neuroplasticity can be demonstrated by highly sensitive MRI techniques of DSC and DTI. HBOT can induce cerebral angiogenesis and improve both white and gray microstructures indicating regeneration of nerve fibers. The micro structural changes correlate with the neurocognitive improvements.

Original languageEnglish
Article number508
JournalFrontiers in Human Neuroscience
Volume11
DOIs
StatePublished - 19 Oct 2017

Bibliographical note

Publisher Copyright:
© 2017 Tal, Hadanny, Sasson, Suzin and Efrati.

Keywords

  • Angiogenesis
  • DTI
  • Hyperbaric oxygen
  • MRI
  • Perfusion
  • Post-concussion
  • TBI
  • Tractography

Fingerprint

Dive into the research topics of 'Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients'. Together they form a unique fingerprint.

Cite this