Hyper-Reactivity to Salience Limits Social Interaction Among Infants Born Pre-term and Infant Siblings of Children With ASD

Michal Zivan, Iris Morag, Jessica Yarmolovsky, Ronny Geva

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The ability to engage attention with selected stimuli is essential for infants to explore the world and process information relating to their surroundings. There are two main populations with a higher risk to develop attentional and social deficits whose deficits may arise from difficulties in regulating attention to salient cues: (1) siblings of children diagnosed with Autism; and (2) infants who were born pre-term. This study investigated infants' (N = 97) attention-engagement and pupil-dilation (PD) at 9 months of age, using a gaze-contingent paradigm and a structured social interaction. Specifically, we explored attention to stimuli with simple salient features (e.g., clear defined shapes, colors, and motions) vs. more complex non-social cues (amorphous shapes, colors, and motions) and social interaction in typically developing infants (TD, N = 25) and among two groups of infants at-risk to develop social difficulties (pre-terms, N = 56; siblings of children with Autism, N = 16). Findings show that the two risk groups preferred stimuli with simple features (F = 11.306, p < 0.001), accompanied by increased PD (F = 6.6, p < 0.001). Specifically, pre-term infants showed increased PD toward simple vs. complex stimuli (p < 0.001), while siblings showed a pervasive hyper-arousal to both simple and complex stimuli. Infants in the TD group preferred complex stimuli with no change in PD. Finally, the preference for the simple stimulus mediated the relationship between increased risk for social difficulties and decreased engagement duration in face-to-face interaction with the experimenter. Results suggest that activation of the attention-salience network shapes social abilities at infancy. Further, hyper-reactivity to salient stimuli limits social interaction among infants born pre-term and siblings of children with ASD.

Original languageEnglish
Article number646838
JournalFrontiers in Psychiatry
Volume12
DOIs
StatePublished - 14 May 2021

Bibliographical note

Publisher Copyright:
© Copyright © 2021 Zivan, Morag, Yarmolovsky and Geva.

Funding

This research was funded by the Israel (1510/16) awarded to RG. We thank the parents and infants who participated in this study, as well as the medical team at Sheba hospital's NICU. Funding. This research was funded by the Israel Science Foundation (1510/16) awarded to RG.

FundersFunder number
Israel Science Foundation1510/16
medical team at Sheba hospital's NICU

    Keywords

    • arousal
    • autism
    • gaze tracking
    • infant behavior
    • prematurity
    • pupil diameter
    • social behavior

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