Hydrogen bonding in Pt ammine complexes

Morris Krauss; Harold Basch; K. J. Miller

doi:10.1016/0009-2614(88)80334-8

Hydrogen bonding in Pt ammine complexes

Morris Krauss, Harold Basch, K. J. Miller

Department of Chemistry

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12 Scopus citations

Abstract

Hydrogen bonding stabilizes the binding of Pt ammine cations to oligonucleotides. Model calculations explore the energetics of the binding of the ammine to G (O6) in PtA₃G (A = ammine, G = guanine) and the intermolecular binding of a carbonyl oxygen to the aremine in a complex of PtA₄ and formaldehyde as a model of binding to carbonyl sites in thymine. Hydrogen-bondig interaction to the G(O6) site is weak but permits the close approach of the O6 and H atoms. Intermolecular hydrogen bonding is strong, as expected for an optimal ionic hydrogen bond.

Original language	English
Pages (from-to)	577-580
Number of pages	4
Journal	Chemical Physics Letters
Volume	148
Issue number	6
DOIs	https://doi.org/10.1016/0009-2614(88)80334-8
State	Published - 29 Jul 1988

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abstract = "Hydrogen bonding stabilizes the binding of Pt ammine cations to oligonucleotides. Model calculations explore the energetics of the binding of the ammine to G (O6) in PtA3G (A = ammine, G = guanine) and the intermolecular binding of a carbonyl oxygen to the aremine in a complex of PtA4 and formaldehyde as a model of binding to carbonyl sites in thymine. Hydrogen-bondig interaction to the G(O6) site is weak but permits the close approach of the O6 and H atoms. Intermolecular hydrogen bonding is strong, as expected for an optimal ionic hydrogen bond.",

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AB - Hydrogen bonding stabilizes the binding of Pt ammine cations to oligonucleotides. Model calculations explore the energetics of the binding of the ammine to G (O6) in PtA3G (A = ammine, G = guanine) and the intermolecular binding of a carbonyl oxygen to the aremine in a complex of PtA4 and formaldehyde as a model of binding to carbonyl sites in thymine. Hydrogen-bondig interaction to the G(O6) site is weak but permits the close approach of the O6 and H atoms. Intermolecular hydrogen bonding is strong, as expected for an optimal ionic hydrogen bond.

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Hydrogen bonding in Pt ammine complexes

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