Hybrid photodetector for single-molecule spectroscopy and microscopy

X. Michalet, Adrian Cheng, Joshua Antelman, Motohiro Suyama, Katsushi Arisaka, Shimon Weiss

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

37 Scopus citations


We report benchmark tests of a new single-photon counting detector based on a GaAsP photocathode and an electron-bombarded avalanche photodiode developed by Hamamatsu Photonics. We compare its performance with those of standard Geiger-mode avalanche photodiodes. We show its advantages for FCS due to the absence of after-pulsing and for fluorescence lifetime measurements due to its excellent time resolution. Its large sensitive area also greatly simplifies setup alignment. Its spectral sensitivity being similar to that of recently introduced CMOS SPADs, this new detector could become a valuable tool for single-molecule fluorescence measurements, as well as for many other applications.

Original languageEnglish
Title of host publicationSingle Molecule Spectroscopy and Imaging
StatePublished - 2008
Externally publishedYes
EventSingle Molecule Spectroscopy and Imaging - San Jose, CA, United States
Duration: 19 Jan 200821 Jan 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceSingle Molecule Spectroscopy and Imaging
Country/TerritoryUnited States
CitySan Jose, CA


  • Afterpulsing
  • FCS
  • Fluorescence
  • Hybrid photodetector
  • Lifetime
  • Microscopy
  • Photocathode
  • Single-molecule
  • Spectroscopy


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