Human papillomavirus associated with vaginal intraepithelial neoplasia in women exposed to diethylstilbestrol in utero

Jacob Bornstein, Raymond H. Kaufman, Ervin Adam, Karen Adler-Storthz

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Abstract

Five out of 959 young women, exposed to diethylstilbestrol (DES) in utero, developed vaginal intraepithelial neoplasia while they were under follow-up in the Diethylstilbestrol Adenosis Project at Baylor College of Medicine, Houston, Texas. We suggest that the development of the vaginal intraepithelial neoplasia at a younger age than usual may be caused by a higher susceptibility of the DES-exposed patient to factors associated with the development of intraepithelial neoplasia. A common finding in all five women was the detection of the deoxyribonucleic acid (DNA) of human papillomavirus types 6 or 16 in their lesions, using highstringency in situ hybridization. The role of human papillomavirus and herpes simplex virus in the etiology of intraepithelial neoplasia is discussed. Close follow-up is recommended for DES-exposed patients, especially those who have risk factors known to be associated with genital neoplasia.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalObstetrics and Gynecology
Volume70
Issue number1
StatePublished - Jul 1987
Externally publishedYes

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