Human papillomavirus associated with adenocarcinoma and adenosquamous carcinoma of the cervix: Analysis by in situ hybridization

Alan N. Gordon, Jacob Bornstein, Raymond H. Kaufman, Rolando G. Estrada, Ervin Adams, Karen Adler-Storthz

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The incidence of adenocarcinoma of the cervix appears to be increasing. Recent reports have demonstrated an association between adenocarcinoma of the cervix and human papillomavirus (HPV) by Southern blot hybridizations. In situ deoxyribonucleic acid (DNA) hybridization was performed on paraffin-embedded specimens to localize the source of HPV DNA. In pure adenocarcinoma five of six specimens were positive for HPV DNA. Four specimens contained HPV type 18 and one HPV type 16. Only one of three adenosquamous lesions was positive and it contained both HPV types 16 and 31. These findings suggest an association between HPV and adenocarcinoma of the cervix.

Original languageEnglish
Pages (from-to)345-348
Number of pages4
JournalGynecologic Oncology
Volume35
Issue number3
DOIs
StatePublished - Dec 1989
Externally publishedYes

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