TY - JOUR
T1 - Human papillomavirus associated with adenocarcinoma and adenosquamous carcinoma of the cervix
T2 - Analysis by in situ hybridization
AU - Gordon, Alan N.
AU - Bornstein, Jacob
AU - Kaufman, Raymond H.
AU - Estrada, Rolando G.
AU - Adams, Ervin
AU - Adler-Storthz, Karen
PY - 1989/12
Y1 - 1989/12
N2 - The incidence of adenocarcinoma of the cervix appears to be increasing. Recent reports have demonstrated an association between adenocarcinoma of the cervix and human papillomavirus (HPV) by Southern blot hybridizations. In situ deoxyribonucleic acid (DNA) hybridization was performed on paraffin-embedded specimens to localize the source of HPV DNA. In pure adenocarcinoma five of six specimens were positive for HPV DNA. Four specimens contained HPV type 18 and one HPV type 16. Only one of three adenosquamous lesions was positive and it contained both HPV types 16 and 31. These findings suggest an association between HPV and adenocarcinoma of the cervix.
AB - The incidence of adenocarcinoma of the cervix appears to be increasing. Recent reports have demonstrated an association between adenocarcinoma of the cervix and human papillomavirus (HPV) by Southern blot hybridizations. In situ deoxyribonucleic acid (DNA) hybridization was performed on paraffin-embedded specimens to localize the source of HPV DNA. In pure adenocarcinoma five of six specimens were positive for HPV DNA. Four specimens contained HPV type 18 and one HPV type 16. Only one of three adenosquamous lesions was positive and it contained both HPV types 16 and 31. These findings suggest an association between HPV and adenocarcinoma of the cervix.
UR - http://www.scopus.com/inward/record.url?scp=0024818807&partnerID=8YFLogxK
U2 - 10.1016/0090-8258(89)90076-0
DO - 10.1016/0090-8258(89)90076-0
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C2 - 2557270
AN - SCOPUS:0024818807
SN - 0090-8258
VL - 35
SP - 345
EP - 348
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 3
ER -