Abstract
Human papillomavirus deoxyribonucleic acid were detected in tissue specimens from 38 of 46 patients (83%) with squamous cell carcinoma in situ of the vulva. Herpes simplex virus type 2-related antigen ICSP 34 35 was demonstrated in 23 of the lesions (50%), and antibodies to herpes simplex virus types 1 and 2 were found in 74% and 65% of the serum samples tested, respectively. Both human papillomavirus deoxyribonucleic acid and herpes simplex virus type 2 antigen were detected in 19 cases (41%). Correlation of human papillomavirus type to the ages of the patients revealed that types 16, 18, and 31 are most often seen in older patients, although the frequencies do not differ significantly. No relationship between the presence or absence of herpes simplex virus type 2-related angitgen to age of the patient was observed.
| Original language | English |
|---|---|
| Pages (from-to) | 862-869 |
| Number of pages | 8 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 158 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1988 |
| Externally published | Yes |
Bibliographical note
Funding Information:From the Departments of Obstetrics and Gynecology and of Virology and Epidemiology, Baylor College ofMedicine, and Department of Microbiology, University of Texas Dental Branch Supported in part by Grant No, ROI DE07008 from the National Institutes of Health and The Women's Fund for Research and Education, Houston, Texas, Presented at the Sixth AnnualMeeting ofthe American Gynecological andObstetricalSociety,Phoenix, Arizona, September10-12, 1987.
Funding
From the Departments of Obstetrics and Gynecology and of Virology and Epidemiology, Baylor College ofMedicine, and Department of Microbiology, University of Texas Dental Branch Supported in part by Grant No, ROI DE07008 from the National Institutes of Health and The Women's Fund for Research and Education, Houston, Texas, Presented at the Sixth AnnualMeeting ofthe American Gynecological andObstetricalSociety,Phoenix, Arizona, September10-12, 1987.
| Funders | Funder number |
|---|---|
| Baylor College ofMedicine | |
| Department of Microbiology, University of Texas Dental Branch Supported | ROI DE07008 |
| Departments of Obstetrics and Gynecology and of Virology and Epidemiology | |
| Women's Fund for Research and Education, Houston, Texas, Presented at the Sixth AnnualMeeting ofthe American Gynecological andObstetricalSociety | |
| National Institutes of Health | |
| National Institute of Dental and Craniofacial Research | R01DE007008 |
Keywords
- Human papillomavirus
- herpes simplex virus
- in situ hybridization
- vulvar squamous cell carcinoma