Human metapneumovirus prevalence during 2019-2021 in Israel is influenced by the COVID-19 pandemic

Michal Stein; Hodaya Cohen; Ital Nemet; Nofar Atari; Limor Kliker; Ilana S. Fratty; Efrat Bucris; Miranda Geva; Ella Mendelson; Neta Zuckerman; Michal Mandelboim

doi:10.1016/j.ijid.2022.04.037

Human metapneumovirus prevalence during 2019-2021 in Israel is influenced by the COVID-19 pandemic

Michal Stein, Hodaya Cohen, Ital Nemet, Nofar Atari, Limor Kliker, Ilana S. Fratty, Efrat Bucris, Miranda Geva, Ella Mendelson, Neta Zuckerman, Michal Mandelboim

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Objectives: To compare infection rates and circulating subtypes of human metapneumovirus (hMPV) before (2019-2020) and after the emergence of coronavirus disease 2019 (COVID-19) (2021) in Israel. Methods: In total, 12,718 respiratory samples were collected from hospitalized patients of all ages during the years 2019 to 2021 at the Sheba Medical Center in Israel and subjected to reverse transcription-polymerase chain reaction analysis. In addition, whole-genome sequencing was performed to characterize the subtypes of hMPV circulating in Israel between 2019 and 2021. Results: A total of 481 samples were found positive for hMPV. Before the emergence of COVID-19, hMPV peaked in winter months and declined thereafter. In sharp contrast, during the COVID-19 pandemic, we observed a delayed peak in hMPV infection cases and higher infection of young children. Viral sequencing showed a shift in the most prevalent circulating hMPV strain from A2b to B1 during the years 2019, 2020, and 2021. Conclusion: Compared with the years before the COVID-19 pandemic, in 2021, hMPV mostly affected young children, and the most prevalent circulating subtype shifted from A2b in 2019 to B1.

Original language	English
Pages (from-to)	205-209
Number of pages	5
Journal	International Journal of Infectious Diseases
Volume	120
DOIs	https://doi.org/10.1016/j.ijid.2022.04.037
State	Published - Jul 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 The Authors

Funding

None. The institutional review board of the Sheba Medical Center approved this study (Helsinki Number 7688-20-SMC). Nasopharyngeal swabs or aspirate samples were collected at the Chaim Sheba Medical Center and from other Israeli hospitals as part of the routine sampling performed in the clinical virology laboratory. The samples were tested and analyzed for the presence of various viruses as part of the routine tests performed in the Chaim Sheba Medical Center. The work described in this paper is an anonymous retrospective study; hence, informed consent (either written or verbal) was not required.

Funders	Funder number
Chaim Sheba Medical Center

Keywords

Phylogeny
Pneumoviridae
Respiratory system
Viruses

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ijid.2022.04.037

Cite this

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title = "Human metapneumovirus prevalence during 2019-2021 in Israel is influenced by the COVID-19 pandemic",

abstract = "Objectives: To compare infection rates and circulating subtypes of human metapneumovirus (hMPV) before (2019-2020) and after the emergence of coronavirus disease 2019 (COVID-19) (2021) in Israel. Methods: In total, 12,718 respiratory samples were collected from hospitalized patients of all ages during the years 2019 to 2021 at the Sheba Medical Center in Israel and subjected to reverse transcription-polymerase chain reaction analysis. In addition, whole-genome sequencing was performed to characterize the subtypes of hMPV circulating in Israel between 2019 and 2021. Results: A total of 481 samples were found positive for hMPV. Before the emergence of COVID-19, hMPV peaked in winter months and declined thereafter. In sharp contrast, during the COVID-19 pandemic, we observed a delayed peak in hMPV infection cases and higher infection of young children. Viral sequencing showed a shift in the most prevalent circulating hMPV strain from A2b to B1 during the years 2019, 2020, and 2021. Conclusion: Compared with the years before the COVID-19 pandemic, in 2021, hMPV mostly affected young children, and the most prevalent circulating subtype shifted from A2b in 2019 to B1.",

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author = "Michal Stein and Hodaya Cohen and Ital Nemet and Nofar Atari and Limor Kliker and Fratty, {Ilana S.} and Efrat Bucris and Miranda Geva and Ella Mendelson and Neta Zuckerman and Michal Mandelboim",

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AU - Fratty, Ilana S.

AU - Bucris, Efrat

AU - Geva, Miranda

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Human metapneumovirus prevalence during 2019-2021 in Israel is influenced by the COVID-19 pandemic

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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